Heteroaryl-ethynyl derivative compounds and uses thereof
The present invention relates to a heteroaryl-ethynyl derivative compound and uses thereof. Since the heteroaryl-ethynyl derivative of the present invention exhibits excellent inhibitory activity against ABL, it can be usefully used as a therapeutic agent for the above ABL-related diseases. The pres...
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| creator | HWANG DONGKEUN PARK JINHEE KIM KYUNEUN CHOI HWANGEUN LEE YEONGDEOK KIM SUNGHWAN IM HYERIM KO EUNHWA |
| description | The present invention relates to a heteroaryl-ethynyl derivative compound and uses thereof. Since the heteroaryl-ethynyl derivative of the present invention exhibits excellent inhibitory activity against ABL, it can be usefully used as a therapeutic agent for the above ABL-related diseases. The present invention is completed by confirming that the heteroaryl-ethynyl derivative compound represented by chemical formula 1 inhibit the proliferation of ABL-activated cells.
본 발명은 헤테로아릴-에티닐 유도체 화합물 및 이의 용도에 관한 것이다. 본 발명의 헤테로아릴-에티닐 유도체는 ABL에 대해 우수한 억제 활성을 나타내므로, 상기 ABL 관련 질환의 치료제로 유용하게 사용될 수 있다. |
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본 발명은 헤테로아릴-에티닐 유도체 화합물 및 이의 용도에 관한 것이다. 본 발명의 헤테로아릴-에티닐 유도체는 ABL에 대해 우수한 억제 활성을 나타내므로, 상기 ABL 관련 질환의 치료제로 유용하게 사용될 수 있다.</description><language>eng ; kor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220713&DB=EPODOC&CC=KR&NR=20220099503A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220713&DB=EPODOC&CC=KR&NR=20220099503A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HWANG DONGKEUN</creatorcontrib><creatorcontrib>PARK JINHEE</creatorcontrib><creatorcontrib>KIM KYUNEUN</creatorcontrib><creatorcontrib>CHOI HWANGEUN</creatorcontrib><creatorcontrib>LEE YEONGDEOK</creatorcontrib><creatorcontrib>KIM SUNGHWAN</creatorcontrib><creatorcontrib>IM HYERIM</creatorcontrib><creatorcontrib>KO EUNHWA</creatorcontrib><title>Heteroaryl-ethynyl derivative compounds and uses thereof</title><description>The present invention relates to a heteroaryl-ethynyl derivative compound and uses thereof. Since the heteroaryl-ethynyl derivative of the present invention exhibits excellent inhibitory activity against ABL, it can be usefully used as a therapeutic agent for the above ABL-related diseases. The present invention is completed by confirming that the heteroaryl-ethynyl derivative compound represented by chemical formula 1 inhibit the proliferation of ABL-activated cells.
본 발명은 헤테로아릴-에티닐 유도체 화합물 및 이의 용도에 관한 것이다. 본 발명의 헤테로아릴-에티닐 유도체는 ABL에 대해 우수한 억제 활성을 나타내므로, 상기 ABL 관련 질환의 치료제로 유용하게 사용될 수 있다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDwSC1JLcpPLKrM0U0tyajMq8xRSEktyixLLMksS1VIzs8tyC_NSylWSMxLUSgtTi1WKMlILUrNT-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfHeQUYGRkYGBpaWpgbGjsbEqQIAHtsv3w</recordid><startdate>20220713</startdate><enddate>20220713</enddate><creator>HWANG DONGKEUN</creator><creator>PARK JINHEE</creator><creator>KIM KYUNEUN</creator><creator>CHOI HWANGEUN</creator><creator>LEE YEONGDEOK</creator><creator>KIM SUNGHWAN</creator><creator>IM HYERIM</creator><creator>KO EUNHWA</creator><scope>EVB</scope></search><sort><creationdate>20220713</creationdate><title>Heteroaryl-ethynyl derivative compounds and uses thereof</title><author>HWANG DONGKEUN ; PARK JINHEE ; KIM KYUNEUN ; CHOI HWANGEUN ; LEE YEONGDEOK ; KIM SUNGHWAN ; IM HYERIM ; KO EUNHWA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220099503A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HWANG DONGKEUN</creatorcontrib><creatorcontrib>PARK JINHEE</creatorcontrib><creatorcontrib>KIM KYUNEUN</creatorcontrib><creatorcontrib>CHOI HWANGEUN</creatorcontrib><creatorcontrib>LEE YEONGDEOK</creatorcontrib><creatorcontrib>KIM SUNGHWAN</creatorcontrib><creatorcontrib>IM HYERIM</creatorcontrib><creatorcontrib>KO EUNHWA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HWANG DONGKEUN</au><au>PARK JINHEE</au><au>KIM KYUNEUN</au><au>CHOI HWANGEUN</au><au>LEE YEONGDEOK</au><au>KIM SUNGHWAN</au><au>IM HYERIM</au><au>KO EUNHWA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Heteroaryl-ethynyl derivative compounds and uses thereof</title><date>2022-07-13</date><risdate>2022</risdate><abstract>The present invention relates to a heteroaryl-ethynyl derivative compound and uses thereof. Since the heteroaryl-ethynyl derivative of the present invention exhibits excellent inhibitory activity against ABL, it can be usefully used as a therapeutic agent for the above ABL-related diseases. The present invention is completed by confirming that the heteroaryl-ethynyl derivative compound represented by chemical formula 1 inhibit the proliferation of ABL-activated cells.
본 발명은 헤테로아릴-에티닐 유도체 화합물 및 이의 용도에 관한 것이다. 본 발명의 헤테로아릴-에티닐 유도체는 ABL에 대해 우수한 억제 활성을 나타내므로, 상기 ABL 관련 질환의 치료제로 유용하게 사용될 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Heteroaryl-ethynyl derivative compounds and uses thereof |
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