METHOD FOR PREDICTING THE RESPONSE AND PROGNOSIS TO CHEMOTHERAPY

The present application provides a method for providing information for predicting a response and a prognosis to anticancer drug treatment. The present application comprises the following steps of: extracting a plurality of differentially expressed genes according to a cancer progression stage; gene...

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Bibliographische Detailangaben
Hauptverfasser:	EOM JIN SEOB, LIM SUN GYO, LEE JEONG HOON
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS PHYSICS
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Beschreibung
Zusammenfassung:	The present application provides a method for providing information for predicting a response and a prognosis to anticancer drug treatment. The present application comprises the following steps of: extracting a plurality of differentially expressed genes according to a cancer progression stage; generating a plurality of gene modules by grouping the plurality of genes; extracting an eigengene of each gene module of the plurality of gene modules; and analyzing a correlation between the eigengene and drug responsiveness. The step of analyzing a correlation comprises a step of connecting information contained in the eigengene with a drug responsiveness database. 본원은 암의 진행 단계(stage)에 따라 차별적으로 발현된 복수의 유전자들을 추출하는 단계, 상기 복수의 유전자들을 그룹화하여 복수의 유전자 모듈들을 생성하는 단계, 상기 복수의 유전자 모듈들의 각 유전자 모듈의 고유 유전자(eigengene)를 추출하는 단계 및 상기 고유 유전자 및 약물 반응성의 상관관계를 분석하는 단계를 포함하고, 상기 상관관계를 분석하는 단계는 상기 고유 유전자에 포함된 정보를 약물 반응성 데이터베이스와 연결시키는 단계를 포함하는 것인, 항암제 치료에 대한 반응 및 예후를 예측하기 위한 정보를 제공하는 방법을 제공한다.