Composition for improving blood circulation or lowering blood pressure comprising an enzyme hydrolysate of antler
The present invention relates to a composition for improving blood circulation or reducing blood pressure and, more specifically, to a composition comprising as an active ingredient a velvet antler extract having a function of enzymolysis for improving blood circulation or reducing blood pressure, w...
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| creator | JEON HYE JIN PARK IL BUM PARK HYUN JE KANG JONGSOO CHUNG KYUNG IN BAEK SIN HWA SONG AERI EOM SEMI |
| description | The present invention relates to a composition for improving blood circulation or reducing blood pressure and, more specifically, to a composition comprising as an active ingredient a velvet antler extract having a function of enzymolysis for improving blood circulation or reducing blood pressure, which has activity of inhibiting angiotensin II-converting enzyme (ACE), includes ACE-inhibiting peptides, promotes enzymatic activity of nitric oxide synthase 3 (NOS3) within an endothelial cell of a blood vessel in a HUVEC cell which is an endothelial cell of a human umbilical vein, inhibits expression of NOS3 genes, and enhances metabolic activity of the HUVEC cell. Further, the composition of the present invention can be used as a health functional food or a pharmaceutical composition.
본 발명은 혈행 개선 또는 혈압 저하용 조성물에 관한 것으로, 보다 상세하게는 녹용 효소분해 추출물을 유효성분으로 포함함으로써 안지오텐신 II 전환 효소(Angiotensin II-converting enzyme, ACE)를 저해하는 활성을 갖고, ACE 저해 펩타이드들을 포함하며, 인간제대정맥 내피세포인 HUVEC cell에서 혈관내피세포 내 산화질소 합성효소(Nitric oxide synthase 3, NOS3)의 효소 활성은 증대시키고, NOS3 유전자 발현을 억제하며, HUVEC cell의 대사활성을 증진시키므로 혈행 개선 또는 혈압 저하용 식품 조성물, 나아가 건강기능식품 또는 약학 조성물로 활용될 수 있다. |
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본 발명은 혈행 개선 또는 혈압 저하용 조성물에 관한 것으로, 보다 상세하게는 녹용 효소분해 추출물을 유효성분으로 포함함으로써 안지오텐신 II 전환 효소(Angiotensin II-converting enzyme, ACE)를 저해하는 활성을 갖고, ACE 저해 펩타이드들을 포함하며, 인간제대정맥 내피세포인 HUVEC cell에서 혈관내피세포 내 산화질소 합성효소(Nitric oxide synthase 3, NOS3)의 효소 활성은 증대시키고, NOS3 유전자 발현을 억제하며, HUVEC cell의 대사활성을 증진시키므로 혈행 개선 또는 혈압 저하용 식품 조성물, 나아가 건강기능식품 또는 약학 조성물로 활용될 수 있다.</description><language>eng ; kor</language><subject>FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220707&DB=EPODOC&CC=KR&NR=20220095725A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220707&DB=EPODOC&CC=KR&NR=20220095725A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JEON HYE JIN</creatorcontrib><creatorcontrib>PARK IL BUM</creatorcontrib><creatorcontrib>PARK HYUN JE</creatorcontrib><creatorcontrib>KANG JONGSOO</creatorcontrib><creatorcontrib>CHUNG KYUNG IN</creatorcontrib><creatorcontrib>BAEK SIN HWA</creatorcontrib><creatorcontrib>SONG AERI</creatorcontrib><creatorcontrib>EOM SEMI</creatorcontrib><title>Composition for improving blood circulation or lowering blood pressure comprising an enzyme hydrolysate of antler</title><description>The present invention relates to a composition for improving blood circulation or reducing blood pressure and, more specifically, to a composition comprising as an active ingredient a velvet antler extract having a function of enzymolysis for improving blood circulation or reducing blood pressure, which has activity of inhibiting angiotensin II-converting enzyme (ACE), includes ACE-inhibiting peptides, promotes enzymatic activity of nitric oxide synthase 3 (NOS3) within an endothelial cell of a blood vessel in a HUVEC cell which is an endothelial cell of a human umbilical vein, inhibits expression of NOS3 genes, and enhances metabolic activity of the HUVEC cell. Further, the composition of the present invention can be used as a health functional food or a pharmaceutical composition.
본 발명은 혈행 개선 또는 혈압 저하용 조성물에 관한 것으로, 보다 상세하게는 녹용 효소분해 추출물을 유효성분으로 포함함으로써 안지오텐신 II 전환 효소(Angiotensin II-converting enzyme, ACE)를 저해하는 활성을 갖고, ACE 저해 펩타이드들을 포함하며, 인간제대정맥 내피세포인 HUVEC cell에서 혈관내피세포 내 산화질소 합성효소(Nitric oxide synthase 3, NOS3)의 효소 활성은 증대시키고, NOS3 유전자 발현을 억제하며, HUVEC cell의 대사활성을 증진시키므로 혈행 개선 또는 혈압 저하용 식품 조성물, 나아가 건강기능식품 또는 약학 조성물로 활용될 수 있다.</description><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzDELwjAQhuEuDqL-hwNnoUSKOEpRBDdxLzG9aiDNxbtUib_eKIKr0zc8H--4uNXUBxIbLXnoiMH2gelu_QXOjqgFY9kMTn88s6MH8k8Do8jACCZn2MpbtAf0z9QjXFPL5JLoiEBdhuiQp8Wo005w9t1JMd9tT_V-gYEalKANeozN4ahKpcpyXa1UtVn-93oBdv5F4Q</recordid><startdate>20220707</startdate><enddate>20220707</enddate><creator>JEON HYE JIN</creator><creator>PARK IL BUM</creator><creator>PARK HYUN JE</creator><creator>KANG JONGSOO</creator><creator>CHUNG KYUNG IN</creator><creator>BAEK SIN HWA</creator><creator>SONG AERI</creator><creator>EOM SEMI</creator><scope>EVB</scope></search><sort><creationdate>20220707</creationdate><title>Composition for improving blood circulation or lowering blood pressure comprising an enzyme hydrolysate of antler</title><author>JEON HYE JIN ; PARK IL BUM ; PARK HYUN JE ; KANG JONGSOO ; CHUNG KYUNG IN ; BAEK SIN HWA ; SONG AERI ; EOM SEMI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20220095725A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2022</creationdate><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>JEON HYE JIN</creatorcontrib><creatorcontrib>PARK IL BUM</creatorcontrib><creatorcontrib>PARK HYUN JE</creatorcontrib><creatorcontrib>KANG JONGSOO</creatorcontrib><creatorcontrib>CHUNG KYUNG IN</creatorcontrib><creatorcontrib>BAEK SIN HWA</creatorcontrib><creatorcontrib>SONG AERI</creatorcontrib><creatorcontrib>EOM SEMI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JEON HYE JIN</au><au>PARK IL BUM</au><au>PARK HYUN JE</au><au>KANG JONGSOO</au><au>CHUNG KYUNG IN</au><au>BAEK SIN HWA</au><au>SONG AERI</au><au>EOM SEMI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Composition for improving blood circulation or lowering blood pressure comprising an enzyme hydrolysate of antler</title><date>2022-07-07</date><risdate>2022</risdate><abstract>The present invention relates to a composition for improving blood circulation or reducing blood pressure and, more specifically, to a composition comprising as an active ingredient a velvet antler extract having a function of enzymolysis for improving blood circulation or reducing blood pressure, which has activity of inhibiting angiotensin II-converting enzyme (ACE), includes ACE-inhibiting peptides, promotes enzymatic activity of nitric oxide synthase 3 (NOS3) within an endothelial cell of a blood vessel in a HUVEC cell which is an endothelial cell of a human umbilical vein, inhibits expression of NOS3 genes, and enhances metabolic activity of the HUVEC cell. Further, the composition of the present invention can be used as a health functional food or a pharmaceutical composition.
본 발명은 혈행 개선 또는 혈압 저하용 조성물에 관한 것으로, 보다 상세하게는 녹용 효소분해 추출물을 유효성분으로 포함함으로써 안지오텐신 II 전환 효소(Angiotensin II-converting enzyme, ACE)를 저해하는 활성을 갖고, ACE 저해 펩타이드들을 포함하며, 인간제대정맥 내피세포인 HUVEC cell에서 혈관내피세포 내 산화질소 합성효소(Nitric oxide synthase 3, NOS3)의 효소 활성은 증대시키고, NOS3 유전자 발현을 억제하며, HUVEC cell의 대사활성을 증진시키므로 혈행 개선 또는 혈압 저하용 식품 조성물, 나아가 건강기능식품 또는 약학 조성물로 활용될 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | Composition for improving blood circulation or lowering blood pressure comprising an enzyme hydrolysate of antler |
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