ATP-PRT ATP-PRT variant with reduced feedback inhibition by histidine and histidine-producing strain expressing the same

The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having reduced feedback inhibition by histidine and a strain expressing the same. Since the activity can be maintained even at a high histidine concentration, histidine production can increase. In the ATP-...

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Bibliographische Detailangaben
Hauptverfasser:	YANG CHEL MIN, JO YOUNG IL, HAN JONG YUN, KIM YONG SOO
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant having reduced feedback inhibition by histidine and a strain expressing the same. Since the activity can be maintained even at a high histidine concentration, histidine production can increase. In the ATP-phosphoribosyltransferase variant, histidine at position 232 is substituted with lysine or threonine. 본 발명은 히스티딘에 의한 피드백 억제가 감소된 대장균 hisG 유래 ATP-포스포리보실전이효소의 변이체 및 이를 발현하는 균주에 대한 것으로, 높은 히스티딘 농도에서도 활성을 유지하므로 히스티딘 생산을 증가시킬 수 있다.