Classification method of risk group for inducing heart fibrillation and detection device using the same

The present invention relates to a method for classifying a risk group for inducing heart fibrillation to calculate development possibility of cardiac fibrillation in consideration of an alternate onset cycle length (AOCL) and actional potential duration 90 (APD90) and a detection device using the s...

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Bibliographische Detailangaben
Hauptverfasser: YOO YE DAM, JEONG DA UN, LIM KI MOO
Format: Patent
Sprache:eng ; kor
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Zusammenfassung:The present invention relates to a method for classifying a risk group for inducing heart fibrillation to calculate development possibility of cardiac fibrillation in consideration of an alternate onset cycle length (AOCL) and actional potential duration 90 (APD90) and a detection device using the same. According to the present invention, the method comprises the following steps of: applying electrical stimulation to the extracted cardiomyocytes while gradually decreasing a cycle length (CL) to identify an action potential duration restitution (APDR) curve; detecting an AOCL which is a cycle length (CL) when a cardiac alternan is generated in an action potential duration restitution (APDR) curve; and calculating development possibility of cardiac fibrillation in consideration of the AOCL and APD90 of a patient from which the cardiomyocytes were extracted. 심장 빈맥성 세동유발 위험군의 분류방법은 추출한 심근세포에 전기자극을 인가하되 흥분주기(Cycle Length; CL)를 점점 감소시키면서 전기자극을 인가하여 APDR(Action Potential Duration Restitution) 곡선을 파악하는 단계와, APDR(Action Potential Duration Restitution) 곡선에서 교대맥(cardiacalternan)이 생성되었을 때의 흥분주기(Cycle Length; CL)인 교대맥유발 흥분주기(Alternan onset cycle length; AOCL)를 검출하는 단계와, 교대맥유발 흥분주기(Alternan onset cycle length; AOCL) 및 심근세포를 추출한 환자의 APD90(Actional Potential Duration 90)을 고려하여 심장세동 발전 가능성을 산출하는 단계를 포함하는 것을 특징으로 한다.