Compound for inhibiting or degrading androgen receptor and medical uses thereof

The present invention provides a compound with a specific chemical structure or a pharmaceutically acceptable salt thereof, having an activity of inhibiting or degrading an androgen receptor (AR). The present invention provides a composition comprising the compound or the pharmaceutically acceptable...

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Bibliographische Detailangaben
Hauptverfasser:	KIM HYUN JIN, KIM PILHO, PARK BYOUNG CHUL, KIM JEONG HOON, WOO YAEJIN, KIM HANWOOL, CHOI YURI, HA JAE DU, PARK SUNG GOO, RYU JE HO, PARK JI YOUN, KIM SUNHONG, CHO SUNG YUN, BAE ONNURI, LEE CHONG OCK, LEE SONG HEE, HWANG JONG YEON, AHN JUNGMIN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound with a specific chemical structure or a pharmaceutically acceptable salt thereof, having an activity of inhibiting or degrading an androgen receptor (AR). The present invention provides a composition comprising the compound or the pharmaceutically acceptable salt thereof. The present invention provides a pharmaceutical use for the treatment or prevention of AR-related diseases of the compound, the salt thereof, and the composition comprising the same according to the present invention. The present invention also provides a method for treating or preventing AR-related diseases, comprising a step of administering an effective amount of the compound, the salt thereof, or the composition comprising the same according to the present invention to a subject in need thereof. 본 발명은 안드로겐 수용체(androgen receptor; AR)를 저해 또는 분해하는 활성을 갖는 특정 화학구조의 화합물 또는 이의 약학적으로 허용 가능한 염을 제공한다. 본 발명은 이러한 화합물 또는 이의 약학적으로 허용 가능한 염을 포함하는 조성물을 제공한다. 본 발명은 본 발명에 따른 화합물, 이의 염 및 이들을 포함하는 조성물의 AR 관련 질환의 치료 또는 예방용 의약 용도를 제공한다. 본 발명은 또한 본 발명에 따른 화합물, 이의 염 또는 이들을 포함하는 조성물의 유효한 양을 치료가 필요한 개체에게 투여하는 것을 포함하는 AR 관련 질환의 치료 또는 예방 방법을 제공한다.