COVID-19 SARS-CoV2 Novel epitope of SARS-CoV2 causing coronavirus disease COVID-19 and use thereof

The present invention relates to novel epitopes of SARS-CoV2 causing coronavirus (COVID-19) infection, and to a use thereof. In designing a neutralization peptide protein capable of interfering with the binding between the spike protein S1-RBD present on the surface of the coronavirus and hACE2, fro...

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Hauptverfasser:	JI SANG HO, YU WOO KYUNG, LEE YOUNG HO, CHANG IKSOO, LEE AEREE, PARK SONG, KANG MOOSEOK, KIM SANG YEOL, SEO SOUK, PARK SEONGJUN, CHOI SEONG KYOON, LEE JUHWAN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel epitopes of SARS-CoV2 causing coronavirus (COVID-19) infection, and to a use thereof. In designing a neutralization peptide protein capable of interfering with the binding between the spike protein S1-RBD present on the surface of the coronavirus and hACE2, from among the numerous charged amino acids present in the RBD structure, D420, R457, K458, E471, etc., which do not directly interact with hACE2, but exist behind the binding site, were discovered as novel epitopes on the RBD surface. It was confirmed that the novel RBD epitopes strongly interact with the neutralization peptide developed by the present inventors. 본 발명은 코로나바이러스 감염증 COVID-19를 일으키는 SARS-CoV2의 신규 에피토프 및 이의 용도에 관한 것으로서, 코로나 바이러스의 표면에 존재하는 스파이크(Spike) 단백질 S1-RBD와 hACE2 사이의 결합을 방해할 수 있는 중화 펩타이드(neutralization peptide) 단백질을 디자인함에 있어서, RBD 구조 속에 존재하는 수많은 전하를 띈 아미노산들 중에서도 hACE2와 직접 상호작용하지는 않지만, 결합부위 근처의 배후에 존재하는 D420, R457, K458, E471 등을 RBD 표면의 새로운 에피토프로 발굴하였다. 상기 신규 RBD 에피토프는 본 발명자들이 개발한 중화 펩타이드와 강하게 상호작용하는 것을 확인하였다.