Composition for preventing of hyperglycemia by statin

The present invention relates to a pharmaceutical composition for preventing hyperglycemia caused by statins, and statins are most often used as drugs for lowering blood cholesterol levels, but increase the incidence of diabetes, so that in the present invention, as an agent that activates the expre...

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Bibliographische Detailangaben
Hauptverfasser:	BAE EUN JU, PARK BYUNG HYUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to a pharmaceutical composition for preventing hyperglycemia caused by statins, and statins are most often used as drugs for lowering blood cholesterol levels, but increase the incidence of diabetes, so that in the present invention, as an agent that activates the expression of sirtuin 6, an agent that inhibits the expression of microRNA (miR)-495 or an agent that promotes FoxO1 deacetylation is administered in combination with a statin to induce hyperglycemia caused by statin to prevent. Therefore, the present invention enables appropriate treatment for patients with cardiovascular disease. 본 발명은 스타틴에 의한 고혈당을 예방하기 위한 약학적 조성물에 관한 것으로서, 스타틴은 혈중 콜레스테롤 수치를 강하하는 약제로서 가장 많이 사용되나 당뇨병 발병률을 증가시키므로, 본 발명은 시르투인 6(sirtuin 6)의 발현을 활성화(activation)하는 제제로서 microRNA(miR)-495의 발현을 억제하는 제제 또는 FoxO1의 탈아세틸화를 촉진하는 제제를 스타틴과 병용 투여하여 스타틴에 의한 고혈당을 예방하는 바, 스타틴을 복용해야 하는 심혈관질환 환자들에게 적절한 치료가 가능하게 한다.