ANTI PCSK9 ANTIBODY AND USE THEREOF

An anti-PCSK9 antibody of the present invention specifically binds to PCSK9 even though it binds to an epitope different from the epitope of a conventional anti-PCSK9 antibody. In particular, the binding force with PCSK9 is very good. Therefore, the anti-PCSK9 antibody can effectively block the bind...

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Bibliographische Detailangaben
Hauptverfasser:	PARK JOOWOONG, CHO ZEUNGKEUN, OH DAESEOK, KANG TAEWOOK
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	An anti-PCSK9 antibody of the present invention specifically binds to PCSK9 even though it binds to an epitope different from the epitope of a conventional anti-PCSK9 antibody. In particular, the binding force with PCSK9 is very good. Therefore, the anti-PCSK9 antibody can effectively block the binding of LDLR to plasma PCSK9. Therefore, it is possible to prevent absorption and degradation of LDLR. Therefore, the anti-PCSK antibody can be usefully used to treat or prevent hypercholesterolemia, hyperlipidemia, atherosclerotic cardiovascular disease (ACVD), acute coronary syndrome (ACS), hypertension, diabetes, stroke, Alzheimer's disease, and dyslipidemia. 본 발명의 항 PCSK9 항체는 종래의 항 PCSK9 항체와 상이한 에피토프에 결합함에도 PCSK9과 특이적으로 결합한다. 특히, PCSK9과의 결합력이 매우 우수하다. 따라서, 항기 항 PCSK9 항체는 LDLR과 혈장 PCSK9의 결합을 효과적으로 차단할 수 있다. 그러므로, 이에 의해 LDLR의 흡수 및 분해를 방지할 수 있다. 따라서, 상기 항 PCSK 항체는 고콜레스테롤혈증, 고지혈증, 죽상경화성 심혈관질환(ACVD), 급성관상동맥증후군(ACS), 고혈압, 당뇨병, 뇌졸중, 알츠하이머 및 이상지질혈증을 치료 또는 예방하는데 유용하게 사용될 수 있다.