HMG-CoA HMG-CoA Reductase Degradation Inducing Compound
The present invention relates to a compound which induces HMG-CoA reductase degradation. Specifically, the present invention relates to a bifunctional compound in which a type 1 statin derivative and an E3 ubiquitin ligase binding moiety are linked by a chemical linker, a method for manufacturing th...
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| creator | HYE GUK RYU HWA JIN LEE SEONG HOON KIM SI WOO CHOI EUN BIN LEE JI HOON RYU IM SUK MIN SAN HA SON SOO HEE RYU JUN KYU LEE |
| description | The present invention relates to a compound which induces HMG-CoA reductase degradation. Specifically, the present invention relates to a bifunctional compound in which a type 1 statin derivative and an E3 ubiquitin ligase binding moiety are linked by a chemical linker, a method for manufacturing the same, a method for decomposing HMG-CoA reductase using the same, and a preventive or therapeutic use of CoA reductase-related diseases comprising the same.
본 발명은 HMG-CoA 환원효소 분해 유도 화합물에 관한 것이다. 구체적으로, 본 발명은 제1형 스타틴 유도체와 E3 유비퀴틴 라이게이즈 결합 모이어티가 화학적 링커로 연결된 이기능성 화합물, 이의 제조방법, 이를 이용한 HMG-CoA 환원효소의 분해 방법, 및 이를 포함하는 HMG-CoA 환원효소 관련 질환의 예방 또는 치료 용도 등에 관한 것이다. |
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본 발명은 HMG-CoA 환원효소 분해 유도 화합물에 관한 것이다. 구체적으로, 본 발명은 제1형 스타틴 유도체와 E3 유비퀴틴 라이게이즈 결합 모이어티가 화학적 링커로 연결된 이기능성 화합물, 이의 제조방법, 이를 이용한 HMG-CoA 환원효소의 분해 방법, 및 이를 포함하는 HMG-CoA 환원효소 관련 질환의 예방 또는 치료 용도 등에 관한 것이다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDD38HXXdc53VIDRQakppcklicWpCi6p6UWJKYklmfl5Cp55QNHMvHQF5_zcgvzSvBQeBta0xJziVF4ozc2g7OYa4uyhm1qQH59aXJCYnJqXWhLvHWRkYGRoYGhkZG5g4WhMnCoAkrgs_A</recordid><startdate>20211012</startdate><enddate>20211012</enddate><creator>HYE GUK RYU</creator><creator>HWA JIN LEE</creator><creator>SEONG HOON KIM</creator><creator>SI WOO CHOI</creator><creator>EUN BIN LEE</creator><creator>JI HOON RYU</creator><creator>IM SUK MIN</creator><creator>SAN HA SON</creator><creator>SOO HEE RYU</creator><creator>JUN KYU LEE</creator><scope>EVB</scope></search><sort><creationdate>20211012</creationdate><title>HMG-CoA HMG-CoA Reductase Degradation Inducing Compound</title><author>HYE GUK RYU ; HWA JIN LEE ; SEONG HOON KIM ; SI WOO CHOI ; EUN BIN LEE ; JI HOON RYU ; IM SUK MIN ; SAN HA SON ; SOO HEE RYU ; JUN KYU LEE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20210122708A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HYE GUK RYU</creatorcontrib><creatorcontrib>HWA JIN LEE</creatorcontrib><creatorcontrib>SEONG HOON KIM</creatorcontrib><creatorcontrib>SI WOO CHOI</creatorcontrib><creatorcontrib>EUN BIN LEE</creatorcontrib><creatorcontrib>JI HOON RYU</creatorcontrib><creatorcontrib>IM SUK MIN</creatorcontrib><creatorcontrib>SAN HA SON</creatorcontrib><creatorcontrib>SOO HEE RYU</creatorcontrib><creatorcontrib>JUN KYU LEE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HYE GUK RYU</au><au>HWA JIN LEE</au><au>SEONG HOON KIM</au><au>SI WOO CHOI</au><au>EUN BIN LEE</au><au>JI HOON RYU</au><au>IM SUK MIN</au><au>SAN HA SON</au><au>SOO HEE RYU</au><au>JUN KYU LEE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HMG-CoA HMG-CoA Reductase Degradation Inducing Compound</title><date>2021-10-12</date><risdate>2021</risdate><abstract>The present invention relates to a compound which induces HMG-CoA reductase degradation. Specifically, the present invention relates to a bifunctional compound in which a type 1 statin derivative and an E3 ubiquitin ligase binding moiety are linked by a chemical linker, a method for manufacturing the same, a method for decomposing HMG-CoA reductase using the same, and a preventive or therapeutic use of CoA reductase-related diseases comprising the same.
본 발명은 HMG-CoA 환원효소 분해 유도 화합물에 관한 것이다. 구체적으로, 본 발명은 제1형 스타틴 유도체와 E3 유비퀴틴 라이게이즈 결합 모이어티가 화학적 링커로 연결된 이기능성 화합물, 이의 제조방법, 이를 이용한 HMG-CoA 환원효소의 분해 방법, 및 이를 포함하는 HMG-CoA 환원효소 관련 질환의 예방 또는 치료 용도 등에 관한 것이다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | HMG-CoA HMG-CoA Reductase Degradation Inducing Compound |
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