HMG-CoA HMG-CoA Reductase Degradation Inducing Compound

The present invention relates to a compound which induces HMG-CoA reductase degradation. Specifically, the present invention relates to a bifunctional compound in which a type 1 statin derivative and an E3 ubiquitin ligase binding moiety are linked by a chemical linker, a method for manufacturing th...

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Bibliographische Detailangaben
Hauptverfasser:	HYE GUK RYU, HWA JIN LEE, SEONG HOON KIM, SI WOO CHOI, EUN BIN LEE, JI HOON RYU, IM SUK MIN, SAN HA SON, SOO HEE RYU, JUN KYU LEE
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a compound which induces HMG-CoA reductase degradation. Specifically, the present invention relates to a bifunctional compound in which a type 1 statin derivative and an E3 ubiquitin ligase binding moiety are linked by a chemical linker, a method for manufacturing the same, a method for decomposing HMG-CoA reductase using the same, and a preventive or therapeutic use of CoA reductase-related diseases comprising the same. 본 발명은 HMG-CoA 환원효소 분해 유도 화합물에 관한 것이다. 구체적으로, 본 발명은 제1형 스타틴 유도체와 E3 유비퀴틴 라이게이즈 결합 모이어티가 화학적 링커로 연결된 이기능성 화합물, 이의 제조방법, 이를 이용한 HMG-CoA 환원효소의 분해 방법, 및 이를 포함하는 HMG-CoA 환원효소 관련 질환의 예방 또는 치료 용도 등에 관한 것이다.