miR-23b-3p MET COMPOSITION FOR INHIBITING METASTASIS OF HEPATOCELLULAR CARCINOMA CONTAINING miR-23b-3p AND MET INHIBITOR AS ACTIVE INGREDIENTS

The present invention relates to a pharmaceutical composition for preventing or inhibiting metastasis of hepatocellular carcinoma, a composition for diagnosing and predicting the metastasis, a kit, and the like. More particularly, the present invention relates to a pharmaceutical composition for pre...

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Bibliographische Detailangaben
Hauptverfasser:	BAE SI HYUN, PARKRI
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a pharmaceutical composition for preventing or inhibiting metastasis of hepatocellular carcinoma, a composition for diagnosing and predicting the metastasis, a kit, and the like. More particularly, the present invention relates to a pharmaceutical composition for preventing or inhibiting metastasis of hepatocellular carcinoma which can effectively prevent and inhibit hepatocellular carcinoma and the metastasis thereof by including miR-23b-3p and an MET inhibitor and thus inhibiting epithelial mesenchymal migration of hepatocellular carcinoma cells; a composition for diagnosing the hepatocellular carcinoma and the metastasis thereof; a kit comprising the composition; and a method of providing information on the diagnosis of hepatocellular carcinoma and the metastasis or prognosis of the hepatocellular carcinoma. 본 발명은 간세포암종의 전이 예방 또는 억제용 약학 조성물 및 전이의 진단 및 예측을 위한 조성물, 키트 등에 관한 것으로, 보다 상세하게는 miR-23b-3p 및 MET 억제제를 포함하여, 간세포암종 세포의 상피간엽이행을 억제함으로써 간세포암종 및 이의 전이를 효과적으로 예방 및 억제할 수 있는 간세포암종의 전이 예방 또는 억제용 약학 조성물, 상기 간세포암종의 진단 및 이의 전이 여부를 진단하기 위한 조성물, 상기 조성물을 포함하는 키트 및 상기 간세포암종 진단 및 간세포암종의 전이 또는 예후에 대한 정보를 제공하는 방법에 관한 것이다.