ICK KLC3 Use of ICK and KLC3 for the diagnosis of ciliary injury disease

The present invention relates to a use of ICK and KLC3 for diagnosis of ciliary injury disease, and to a preparation for preventing or treating ciliary injury disease comprising a KLC3 inhibitor, which is proposed as a biomarker for diagnosis of ciliary injury disease by confirming that cilia is dam...

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Bibliographische Detailangaben
Hauptverfasser:	KO JE YEONG, KO HYUK WAN, PARK JONG HOON, RAH GYU YEONG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a use of ICK and KLC3 for diagnosis of ciliary injury disease, and to a preparation for preventing or treating ciliary injury disease comprising a KLC3 inhibitor, which is proposed as a biomarker for diagnosis of ciliary injury disease by confirming that cilia is damaged, cyst is formed and KLC3 protein is increased due to an ICK defect through knock-out in the kidney in animal models, thus proving that ICK defects and increased KLC3 are indicators of ciliary injury. In addition, the present invention provides a KLC3 protein activity inhibitor or a KLC3 mRNA expression inhibitor as a preparation for preventing or treating ciliary injury disease by confirming that the cysts formed by ICK defects in renal epithelial cells are alleviated by inhibiting KLC3 protein. 본 발명은 섬모 손상 질환의 진단을 위한 ICK 및 KLC3의 용도, 및 KLC3 억제제를 포함하는 섬모 손상 질환의 예방 또는 치료용 제제에 관한 것으로, 동물모델의 신장에서 녹아웃(knock out)을 통한 ICK 결함으로 섬모가 손상되고 낭포가 형성되고, KLC3 단백질이 증가하는 것을 확인하여 ICK 결함 및 KLC3 증가가 섬모 손상의 지표라는 것을 입증함으로써, ICK 및 KLC3를 섬모 손상 질환의 진단을 위한 바이오 마커로 제안한다. 또한, 본 발명은 신장 상피세포에서 ICK 결함으로 형성되는 낭포가 KLC3 단백질을 억제로 개선되는 것을 확인함으로써, KLC3 단백질의 활성 억제제 또는 KLC3 mRNA의 발현 억제제를 섬모 손상 질환의 예방 또는 치료용 제제로 제공한다.