RECOMBINANT LENTIVIRUS OVEREXPRESSING CARTILAGE REGENERATION SIGNAL CELL GROWTH FACTOR AND PHARMACEUTICAL COMPOSITION FOR CARTILAGE REGENERATION INCLUDING IT

The present invention relates to a method for manufacturing a cell line overexpressing a cartilage regeneration signal cell growth factor using adipose tissue-derived stem cells and a mixture of cell line cultures manufactured by using the same. Cell lines overexpressing a specific signal substance...

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Bibliographische Detailangaben
Hauptverfasser:	PARK BYEONG MOOK, CHOI SUNG SIK, PARK MEONG JOON, PARK JAE WOO
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a method for manufacturing a cell line overexpressing a cartilage regeneration signal cell growth factor using adipose tissue-derived stem cells and a mixture of cell line cultures manufactured by using the same. Cell lines overexpressing a specific signal substance can standardly manufacture high-concentration mixed CM without changing the content of secretions other than a target substance, and mixed CM can be used as a cartilage regeneration treatment for chondrocyte activation. 본 발명은 지방 조직 유래 줄기세포를 이용한 연골 재생 시그날 세포 성장인자를 과발현하는 세포주 제작방법 및 이를 이용하여 제작된 세포주 배양물들의 혼합물에 관한 것으로, 특정 신호물질을 과발현하는 세포주들은 타겟 물질이외에 다른 분비물의 함량에는 변화가 없이 고농도의 혼합 CM을 표준적으로 제조할 수 있으며, 혼합 CM은 연골세포의 활성화를 위한 연골 재생치료제로 사용될 수 있다.