ASH1L - Composition for preventing or treating of leukemia comprising a benzofuran-pyrazole derivative compound that inhibits ASH1Lhistone methyltransferase activity

The present invention relates to a pharmaceutical composition for preventing or treating leukemia comprising a benzofuran-pyrazole derivative, wherein the composition according to the present invention effectively inhibits ASH1L histone methylase activity, and has an effect of promoting the death of...

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Bibliographische Detailangaben
Hauptverfasser:	SONG JI JOON, YOON JUNG MIN, SHIN YU MI, CHO SUNG JIN, KIM MI YOUNG, CHIN JUNGWOOK, HONG EUNMI
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a pharmaceutical composition for preventing or treating leukemia comprising a benzofuran-pyrazole derivative, wherein the composition according to the present invention effectively inhibits ASH1L histone methylase activity, and has an effect of promoting the death of leukemia cells since the ASH1L histone methylase activity is reduced, thereby being able to be usefully used for preventing or treating leukemia. 본 발명은 벤조퓨란-피라졸 유도체를 포함하는 백혈병의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 조성물은 ASH1L 히스톤 메틸화 효소 활성을 효과적으로 억제하고, 상기 ASH1L 히스톤 메틸화 효소 활성이 저하됨에 따라 백혈병 세포의 사멸을 촉진시키는 효과가 있어, 백혈병을 예방 또는 치료하는데 유용하게 사용할 수 있다.