Cosmetic composition comprising lutein nanoencapsulated with cubosome as an active ingredient

The present invention provides nanoparticles easy to penetrate into the skin by encapsulating lutein derived from PB17 (Auxenochlorella protothecoides, Chlorella minutissima) which is cultured by a PSP method and extracted in a supercritical way. PB17-lutein-encapsulated nanoparticles are cubosomes...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, MOO HYUNG, KIM HONG RAE, IM CHUNG SOON, KIM DA YOUNG, CHOI, WON SEOG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides nanoparticles easy to penetrate into the skin by encapsulating lutein derived from PB17 (Auxenochlorella protothecoides, Chlorella minutissima) which is cultured by a PSP method and extracted in a supercritical way. PB17-lutein-encapsulated nanoparticles are cubosomes made of monoolein and formed into cubic phases. The size of cubosomes containing PB17-lutein is approximately 100-200 nanometers and exhibits 30-40% transmittance in an artificial skin membrane. PB17-lutein encapsulated with cubosomes formed of monoolein presented in the present invention has an excellent skin penetration property, no skin irritation, and excellent antioxidant, whitening and wrinkle alleviation effects. 이 발명은 PSP 방법으로 배양되어 초임계 방식으로 추출된 PB17(Auxenochlorella protothecoides, Chlorella minutissima) 유래 루테인을 캡슐화하여 피부에 침투하기 쉬운 나노입자를 제시한 것이다. PB17-루테인이 캡슐화된 나노입자는 모노올레인으로 만들어지고 큐빅상으로 만들어진 큐보좀이다. PB17-루테인을 함유한 큐보좀의 크기는 대략 100-200 나노미터이고, 인공 피부막에서 30-40% 투과율을 나타낸다. 본 발명에서 제시하는 모노올레인으로 형성된 큐보좀에 캡슐화된 PB17-루테인은 피부침투성이 우수하며 피부자극이 없고, 항산화, 미백 및 주름개선 효과가 우수하다.