4-｛8-아미노-3-[(2S)-1--피롤리딘-2-일]이미다조[1,5-a]-피라진-1-일｝N--벤즈아미드의 제조 공정

4-｛8-아미노-3-[(2S)-1--피롤리딘-2-일]이미다조[1,5-a]-피라진-1-일｝N--벤즈아미드의 제조 공정

본 발명은 일반적으로 4-{8-아미노-3-[(2S)-1-(부트-2-이노일)피롤리딘-2-일]이미다조[1,5-a]피라진-1-일}-N-(피리딘-2-일)-벤즈아미드의 개선된 제조 공정, 특히 4-{8-아미노-3-[(2S)-1-(부트-2-이노일)피롤리딘-2-일]이미다조[1,5-a]피라진-1-일}-N-(피리딘-2-일)벤즈아미드를 제조하기 위한 대규모 공정 및 이러한 공정에 사용된 중간체에 관한 것이다. The present disclosure relates, in general, to improved processes for the prepa...

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Hauptverfasser: LAWLER MICHAEL JOSEPH, GOLDEN MICHAEL DAVID, GARREY RUSTAM FERDINAND, WANG ANGANG, TELFORD ALEXANDER JAMES, EVARTS JERRY, CHAN LAI CHUN, SHORT DAVID ALLEN, VERSTAPPEN MATHILDA MARIA HENRICA, JACKSON LUCINDA VICTORIA, MILLARD KIRSTY JANE, VAN EIJK PETER JOHANNES SERVAAS SAVIO, LITJENS REMY E. J. N, COX ROBERT JOHN, ZIJP ERIC JURRIEN, VOS FRANK L. M, HUGHES SHAUN ALAN, COOPER KATIE GRACE, PHILLIPS ANDREW JOHN, BETHEL PAUL ALLEN, JUNYING QIU
Format: Patent
Sprache:kor
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:본 발명은 일반적으로 4-{8-아미노-3-[(2S)-1-(부트-2-이노일)피롤리딘-2-일]이미다조[1,5-a]피라진-1-일}-N-(피리딘-2-일)-벤즈아미드의 개선된 제조 공정, 특히 4-{8-아미노-3-[(2S)-1-(부트-2-이노일)피롤리딘-2-일]이미다조[1,5-a]피라진-1-일}-N-(피리딘-2-일)벤즈아미드를 제조하기 위한 대규모 공정 및 이러한 공정에 사용된 중간체에 관한 것이다. The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.