Pharmaceutical composition containing edoxaban free base
Disclosed in the present invention are: a pharmaceutical composition containing edoxaban free base which exhibits high solubility and dissolution rate in a neutral region and has excellent productivity in tablet manufacturing; a solid preparation comprising the same; and a method for manufacturing t...
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| Hauptverfasser: | , , , |
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| Format: | Patent |
| Sprache: | eng ; kor |
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| Zusammenfassung: | Disclosed in the present invention are: a pharmaceutical composition containing edoxaban free base which exhibits high solubility and dissolution rate in a neutral region and has excellent productivity in tablet manufacturing; a solid preparation comprising the same; and a method for manufacturing the same. The pharmaceutical composition containing edoxaban free base and citric acid as an acidic additive according to the present invention can also ensure the stability of an active component.
본 발명은 중성 영역에서 높은 용해도 및 용출률을 나타내고 정제 제조시 생산성이 우수한 에독사반 유리 염기 함유 제약 조성물, 이를 포함하는 고형 제제 및 이의 제조방법을 개시한다. |
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