CRISPR/Cas9 Generation of canine dystrophinopathy model by nuclear transfer using CRISPR/Cas9-mediated somatic cells and th Use thereof

The present invention relates to a transgenic dog for a dystrophinopathy model, a method for manufacturing the same, and uses thereof. More specifically, the present invention relates to a use of a transgenic dog knocked out of a dystrophin gene as a disease animal model. 본 발명은 디스트로핀병증 모델용 형질전환 개 및...

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Bibliographische Detailangaben
Hauptverfasser:	LEE SEOK HEE, OH HYUN JU, CHUNG EUGENE, KIM MING JUNG, KIM JIN SOO, KIM GEON A, LEE BYEONG CHUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a transgenic dog for a dystrophinopathy model, a method for manufacturing the same, and uses thereof. More specifically, the present invention relates to a use of a transgenic dog knocked out of a dystrophin gene as a disease animal model. 본 발명은 디스트로핀병증 모델용 형질전환 개 및 이의 제조방법, 그리고 이의 이용에 관한 것으로, 보다 구체적으로는 Dystrophin 유전자를 넉아웃(knock-out) 시킨 형질전환 개를 질환 동물 모델로 이용하는 것에 관한 것이다.