Cacb1 Cacb1 Cacb1-derived peptide Cacb1-derived peptide variants and uses thereof

The present invention relates to a Cacb1-derived peptide, a variant of the Cacb1-derived peptide, a composition for preventing or treating hypertension and a composition for relaxing blood vessels including the same. The Cacb1-derived peptide and the variant of the Cacb1-derived peptide according to...

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Bibliographische Detailangaben
Hauptverfasser:	KIM TAE WAN, YOUN DONG HO, OH TAEHO
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention relates to a Cacb1-derived peptide, a variant of the Cacb1-derived peptide, a composition for preventing or treating hypertension and a composition for relaxing blood vessels including the same. The Cacb1-derived peptide and the variant of the Cacb1-derived peptide according to the present invention have an excellent blood pressure-lowering effect and fewer side effects, and are easy to manufacture and industrialize, and thus can be effectively used in the development of a novel therapeutic agent for hypertension. In addition, the peptide and the variant thereof have a potential vasodilating effect, and thus are expected to be used as a candidate material for a therapeutic agent for diseases that can be treated or ameliorated by vasodilation, such as angina, prostatic hyperplasia, and erectile dysfunction. 본 발명은 Cacb1 유래 펩타이드 및 Cacb1 유래 펩타이드의 변이체 및 이를 포함하는 고혈압 예방 또는 치료용 조성물 및 혈관 이완용 조성물에 관한 것이다. 본 발명의 Cacb1 유래 펩타이드, Cacb1 유래 펩타이드의 변이체는 혈압 하강 효과가 우수하며, 부작용이 적고 제조 및 산업화가 용이하여 새로운 고혈압 치료제 개발에 유용하게 사용될 수 있다. 뿐만 아니라, 잠재적 혈관확장 효과로 협심증, 전립선 비대증, 발기부전 등 혈관확장으로 치료 또는 개선될 수 있는 질환의 치료제 후보물질로 활용될 것으로 기대된다.