NOVEL LATANOPROST INTERMEDIATE AND METHOD FOR PREPARING LATANOPROST WITH HIGH PURITY
The present invention provides a novel latanoprost intermediate represented by chemical formula 1. In chemical formula 1, R is hydrogen or C_1-C_4 alkyl, P is hydrogen or a hydroxy protecting group, at least one P is a hydroxy protecting group. The hydroxy protecting group is represented by chemical...
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| Format: | Patent |
| Sprache: | eng ; kor |
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| Zusammenfassung: | The present invention provides a novel latanoprost intermediate represented by chemical formula 1. In chemical formula 1, R is hydrogen or C_1-C_4 alkyl, P is hydrogen or a hydroxy protecting group, at least one P is a hydroxy protecting group. The hydroxy protecting group is represented by chemical formula 2. In chemical formula 2, R^1 is each independently -NO_2 or C_6-C_18 aryl, and R^1 is fused to a phenyl ring to form a C_10-C_18 aromatic ring.
본 발명의 신규한 라타노프로스트 중간체는 하기 화학식 1로 표현된다. [화학식 1]상기 화학식 1에서, R은 수소 또는 C-C알킬이고, P는 수소 또는 하이드록시기 보호기이고, 적어도 하나 이상의 P는 하이드록시기 보호기이되, 상기 하이드록시기 보호기는 하기 화학식 2로 표시된다. [화학식 2]상기 화학식 2에서 R은 각각 독립적으로 -NO또는 C-C아릴이거나, R이 페닐 고리에 융합(fused)되어 C-C방향족 고리를 형성한다. |
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