A pyrrolopyrimidine derivatives and pharmaceutical composition for use in preventing or treating protein kinase related disease as an active ingredient

The present invention relates to a pyrrolopyrimidine derivative, and a pharmaceutical composition for preventing or treating protein kinase-related diseases containing the same as an active component. The pyrrolopyrimidine derivative has excellent inhibitory activity on various protein kinases inclu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CHUNG SOHYUN, KIM HWAN, MA DAHOON, JUNG MYUNGHO, KIM HYUNKYUNG, JEON HYEONHO, RYU HEESUN, KIM NAM DOO, YUN JUNGYEON, SON JUNG BEOM
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to a pyrrolopyrimidine derivative, and a pharmaceutical composition for preventing or treating protein kinase-related diseases containing the same as an active component. The pyrrolopyrimidine derivative has excellent inhibitory activity on various protein kinases including LRRK2, and has an excellent effect of inhibiting proliferation of triple negative breast cancer cells. Therefore, the pharmaceutical composition containing the pyrrolopyrimidine derivative as the active component can be usefully used for treating or preventing protein kinase-related diseases, in particular cancer, degenerative brain disease, and inflammatory disease, and specifically, can be usefully used for treating triple negative breast cancer. 피롤로피리미딘 유도체 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 피롤로피리미딘 유도체는 LRRK2를 포함하는 다양한 단백질 키나아제에 대한 억제활성이 우수하고, 삼중음성 유방암 세포의 증식을 억제하는 효과가 우수하므로, 이를 유효성분으로 함유하는 약학적 조성물은 단백질 키나아제 관련 질환, 특히, 암, 퇴행성 뇌질환 및 염증질환의 치료 또는 예방에 유용하게 사용될 수 있고, 구체적으로, 삼중음성 유방암의 치료에 유용하게 사용될 수 있다.