Method for the preparation of high purity Palonosetron intermediates
The present invention relates to a method for manufacturing a high purity palonosetron intermediate compound represented by chemical formula 1. The present invention provides a method for manufacturing N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide, represented by chem...
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| creator | HAN JUNG SEOK KIM YEONG TAEK CHOI JI WON OH DO YEON YUN IK HWAN AHN WON KWON HYUK BEOM |
| description | The present invention relates to a method for manufacturing a high purity palonosetron intermediate compound represented by chemical formula 1. The present invention provides a method for manufacturing N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide, represented by chemical formula 1 with a high purity by conducting a reaction with a compound of chemical formula 2, which is a racemic mixture, under conditions of an inorganic base and a mixed solvent.
본 발명은 하기 화학식 1로 표시되는 팔로노세트론 중간체 화합물의 고순도 제조방법에 관한 것으로, 라세믹체인 화학식 2의 화합물과 무기염기류 및 혼합용매의 조건하에서 반응시켜, 화학식 1로 표시되는 N-(1-아자바이사이클로[2.2.2]옥트-3S-일)-1,2,3,4-테트라하이드로나프탈렌-1-일카르복사미드를 고순도로 제조하는 방법을 제공한다. |
| format | Patent |
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본 발명은 하기 화학식 1로 표시되는 팔로노세트론 중간체 화합물의 고순도 제조방법에 관한 것으로, 라세믹체인 화학식 2의 화합물과 무기염기류 및 혼합용매의 조건하에서 반응시켜, 화학식 1로 표시되는 N-(1-아자바이사이클로[2.2.2]옥트-3S-일)-1,2,3,4-테트라하이드로나프탈렌-1-일카르복사미드를 고순도로 제조하는 방법을 제공한다.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHDxTS3JyE9RSMsvUijJSFUoKEotSCxKLMnMz1PIT1PIyEzPUCgoLcosqVQISMzJz8svTi0pAspl5pWkFuWmpmQmlqQW8zCwpiXmFKfyQmluBmU31xBnD93Ugvz41OKCxOTUvNSSeO8gIwMjAwMDMxNzSzNHY-JUAQCsRzQx</recordid><startdate>20200608</startdate><enddate>20200608</enddate><creator>HAN JUNG SEOK</creator><creator>KIM YEONG TAEK</creator><creator>CHOI JI WON</creator><creator>OH DO YEON</creator><creator>YUN IK HWAN</creator><creator>AHN WON</creator><creator>KWON HYUK BEOM</creator><scope>EVB</scope></search><sort><creationdate>20200608</creationdate><title>Method for the preparation of high purity Palonosetron intermediates</title><author>HAN JUNG SEOK ; KIM YEONG TAEK ; CHOI JI WON ; OH DO YEON ; YUN IK HWAN ; AHN WON ; KWON HYUK BEOM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20200064796A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HAN JUNG SEOK</creatorcontrib><creatorcontrib>KIM YEONG TAEK</creatorcontrib><creatorcontrib>CHOI JI WON</creatorcontrib><creatorcontrib>OH DO YEON</creatorcontrib><creatorcontrib>YUN IK HWAN</creatorcontrib><creatorcontrib>AHN WON</creatorcontrib><creatorcontrib>KWON HYUK BEOM</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAN JUNG SEOK</au><au>KIM YEONG TAEK</au><au>CHOI JI WON</au><au>OH DO YEON</au><au>YUN IK HWAN</au><au>AHN WON</au><au>KWON HYUK BEOM</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for the preparation of high purity Palonosetron intermediates</title><date>2020-06-08</date><risdate>2020</risdate><abstract>The present invention relates to a method for manufacturing a high purity palonosetron intermediate compound represented by chemical formula 1. The present invention provides a method for manufacturing N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide, represented by chemical formula 1 with a high purity by conducting a reaction with a compound of chemical formula 2, which is a racemic mixture, under conditions of an inorganic base and a mixed solvent.
본 발명은 하기 화학식 1로 표시되는 팔로노세트론 중간체 화합물의 고순도 제조방법에 관한 것으로, 라세믹체인 화학식 2의 화합물과 무기염기류 및 혼합용매의 조건하에서 반응시켜, 화학식 1로 표시되는 N-(1-아자바이사이클로[2.2.2]옥트-3S-일)-1,2,3,4-테트라하이드로나프탈렌-1-일카르복사미드를 고순도로 제조하는 방법을 제공한다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Method for the preparation of high purity Palonosetron intermediates |
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