Method for the preparation of high purity Palonosetron intermediates
The present invention relates to a method for manufacturing a high purity palonosetron intermediate compound represented by chemical formula 1. The present invention provides a method for manufacturing N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide, represented by chem...
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| Format: | Patent |
| Sprache: | eng ; kor |
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| Zusammenfassung: | The present invention relates to a method for manufacturing a high purity palonosetron intermediate compound represented by chemical formula 1. The present invention provides a method for manufacturing N-(1-azabicyclo[2.2.2]oct-3S-yl)-1,2,3,4-tetrahydronaphthalen-1-ylcarboxamide, represented by chemical formula 1 with a high purity by conducting a reaction with a compound of chemical formula 2, which is a racemic mixture, under conditions of an inorganic base and a mixed solvent.
본 발명은 하기 화학식 1로 표시되는 팔로노세트론 중간체 화합물의 고순도 제조방법에 관한 것으로, 라세믹체인 화학식 2의 화합물과 무기염기류 및 혼합용매의 조건하에서 반응시켜, 화학식 1로 표시되는 N-(1-아자바이사이클로[2.2.2]옥트-3S-일)-1,2,3,4-테트라하이드로나프탈렌-1-일카르복사미드를 고순도로 제조하는 방법을 제공한다. |
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