Bioactive molecules-loaded polymer-cell mixed spheroid and method for preparing thereof

The present invention relates to a polymer-cell mixed spheroid having bioactive factors loaded therein, which uses a fallen leaf-stacking type porous fine polymer particles having the bioactive factors adsorbed thereon, a manufacturing method thereof, and a method for using the same to various appli...

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Bibliographische Detailangaben
Hauptverfasser:	JIN HO LEE, SE HEANG OH, HO YONG KIM, MIN JI KIM, YEOUNG JO JEOUNG, SO YEONG GIM, JUNE HO BYUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a polymer-cell mixed spheroid having bioactive factors loaded therein, which uses a fallen leaf-stacking type porous fine polymer particles having the bioactive factors adsorbed thereon, a manufacturing method thereof, and a method for using the same to various applications. According to the present invention, the bioactive factors are adsorbed on the fallen leaf-stacking type porous fine polymer particles having a unique structure and the fallen leaf-stacking type porous fine polymer particles having the bioactive factors adsorbed thereon are mixed with cells such that the polymer-cell mixed spheroid can be manufactured. Accordingly, the bioactive factors loaded in the polymer are released from the spheroid in a suspended release type, thereby providing an effect of promoting cell differentiation and regeneration in an injured portion. 본 발명은 생리활성인자가 흡착된 낙엽적층형 다공성 고분자 미세입자를 이용한 생리활성인자들이 탑재된 고분자-세포 혼합 스페로이드, 이의 제조방법 및 이를 다양한 용도에 이용하는 사용방법에 관한 것이다. 본 발명에 따르면, 독특한 구조를 가지는 낙엽 적층형 다공성 고분자 미세입자에 생리활성인자를 흡착시키고, 생리활성인자가 흡착된 낙엽적층형 다공성 고분자 미세입자를 세포와 혼합시킨 고분자-세포 혼합 스페로이드를 제조할 수 있으며, 상기 고분자에 탑재된 생리활성인자는 스페로이드로부터 서방형 방출되어 손상된 부위에서 세포의 분화 및 재생을 촉진시키는 효과를 가진다.