1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVE CONJUGATED WITH ALBUMIN
The present invention relates to a glucagon-like peptide-1 derivative conjugated with albumin and, more particularly, to a derivative having albumin conjugated with a certain position of the glucagon-like peptide-1 derivative through a linker, a use thereof and a method for preparing the same. Accor...
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| creator | YANG BYUNG SEOP KIM SUKHWAN SEONG JIHYOUN BAK MI JEONG KWON INCHAN CHO JINHWAN |
| description | The present invention relates to a glucagon-like peptide-1 derivative conjugated with albumin and, more particularly, to a derivative having albumin conjugated with a certain position of the glucagon-like peptide-1 derivative through a linker, a use thereof and a method for preparing the same. According to the present invention, in case of a GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker, albumin is conjugated with a certain position of GLP-1, particularly 13Y or 22F, thereby minimizing a decrease in a medicinal effect due to a steric hindrance. In addition, the derivative according to the present invention increases a half-life in vivo through conjugation with albumin. Accordingly, the GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker may be useful in treating diabetics.
본 발명은 알부민이 결합된 글루카곤 유사 펩타이드-1 유사체에 관한 것이다. 보다 상세하게는 알부민이 링커를 통해 글루카곤 유사 펩타이드-1 유사체의 특정 위치에 결합된 유사체, 이의 용도 및 이의 제조방법에 관한 것이다. 본 발명의 GLP-1 유사체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 GLP-1의 특정 위치, 구체적으로 13Y 또는 22F에 알부민을 결합시켜 입체 장애로 인한 약효 감소를 최소화하였다. 또한, 본 발명에 따른 유사체는 알부민과의 결합을 통해 체내 반감기를 증가시켰다. 따라서, 본 발명의 GLP-1 변이체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 당뇨병을 치료하는데 유용하게 사용될 수 있다. |
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본 발명은 알부민이 결합된 글루카곤 유사 펩타이드-1 유사체에 관한 것이다. 보다 상세하게는 알부민이 링커를 통해 글루카곤 유사 펩타이드-1 유사체의 특정 위치에 결합된 유사체, 이의 용도 및 이의 제조방법에 관한 것이다. 본 발명의 GLP-1 유사체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 GLP-1의 특정 위치, 구체적으로 13Y 또는 22F에 알부민을 결합시켜 입체 장애로 인한 약효 감소를 최소화하였다. 또한, 본 발명에 따른 유사체는 알부민과의 결합을 통해 체내 반감기를 증가시켰다. 따라서, 본 발명의 GLP-1 변이체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 당뇨병을 치료하는데 유용하게 사용될 수 있다.</description><language>eng ; kor</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200603&DB=EPODOC&CC=KR&NR=20200061688A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200603&DB=EPODOC&CC=KR&NR=20200061688A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG BYUNG SEOP</creatorcontrib><creatorcontrib>KIM SUKHWAN</creatorcontrib><creatorcontrib>SEONG JIHYOUN</creatorcontrib><creatorcontrib>BAK MI JEONG</creatorcontrib><creatorcontrib>KWON INCHAN</creatorcontrib><creatorcontrib>CHO JINHWAN</creatorcontrib><title>1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVE CONJUGATED WITH ALBUMIN</title><description>The present invention relates to a glucagon-like peptide-1 derivative conjugated with albumin and, more particularly, to a derivative having albumin conjugated with a certain position of the glucagon-like peptide-1 derivative through a linker, a use thereof and a method for preparing the same. According to the present invention, in case of a GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker, albumin is conjugated with a certain position of GLP-1, particularly 13Y or 22F, thereby minimizing a decrease in a medicinal effect due to a steric hindrance. In addition, the derivative according to the present invention increases a half-life in vivo through conjugation with albumin. Accordingly, the GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker may be useful in treating diabetics.
본 발명은 알부민이 결합된 글루카곤 유사 펩타이드-1 유사체에 관한 것이다. 보다 상세하게는 알부민이 링커를 통해 글루카곤 유사 펩타이드-1 유사체의 특정 위치에 결합된 유사체, 이의 용도 및 이의 제조방법에 관한 것이다. 본 발명의 GLP-1 유사체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 GLP-1의 특정 위치, 구체적으로 13Y 또는 22F에 알부민을 결합시켜 입체 장애로 인한 약효 감소를 최소화하였다. 또한, 본 발명에 따른 유사체는 알부민과의 결합을 통해 체내 반감기를 증가시켰다. 따라서, 본 발명의 GLP-1 변이체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 당뇨병을 치료하는데 유용하게 사용될 수 있다.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAxVHD3CXV2dPf30_Xx9HZVCHANCPF0cdU1VHBxDfIMcwzxDHNVcPb38wp1dwxxdVEI9wzxUHD0cQr19fTjYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXx3kFGBkYGBgZmhmYWFo7GxKkCAHl1Khg</recordid><startdate>20200603</startdate><enddate>20200603</enddate><creator>YANG BYUNG SEOP</creator><creator>KIM SUKHWAN</creator><creator>SEONG JIHYOUN</creator><creator>BAK MI JEONG</creator><creator>KWON INCHAN</creator><creator>CHO JINHWAN</creator><scope>EVB</scope></search><sort><creationdate>20200603</creationdate><title>1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVE CONJUGATED WITH ALBUMIN</title><author>YANG BYUNG SEOP ; KIM SUKHWAN ; SEONG JIHYOUN ; BAK MI JEONG ; KWON INCHAN ; CHO JINHWAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20200061688A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG BYUNG SEOP</creatorcontrib><creatorcontrib>KIM SUKHWAN</creatorcontrib><creatorcontrib>SEONG JIHYOUN</creatorcontrib><creatorcontrib>BAK MI JEONG</creatorcontrib><creatorcontrib>KWON INCHAN</creatorcontrib><creatorcontrib>CHO JINHWAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG BYUNG SEOP</au><au>KIM SUKHWAN</au><au>SEONG JIHYOUN</au><au>BAK MI JEONG</au><au>KWON INCHAN</au><au>CHO JINHWAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVE CONJUGATED WITH ALBUMIN</title><date>2020-06-03</date><risdate>2020</risdate><abstract>The present invention relates to a glucagon-like peptide-1 derivative conjugated with albumin and, more particularly, to a derivative having albumin conjugated with a certain position of the glucagon-like peptide-1 derivative through a linker, a use thereof and a method for preparing the same. According to the present invention, in case of a GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker, albumin is conjugated with a certain position of GLP-1, particularly 13Y or 22F, thereby minimizing a decrease in a medicinal effect due to a steric hindrance. In addition, the derivative according to the present invention increases a half-life in vivo through conjugation with albumin. Accordingly, the GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker may be useful in treating diabetics.
본 발명은 알부민이 결합된 글루카곤 유사 펩타이드-1 유사체에 관한 것이다. 보다 상세하게는 알부민이 링커를 통해 글루카곤 유사 펩타이드-1 유사체의 특정 위치에 결합된 유사체, 이의 용도 및 이의 제조방법에 관한 것이다. 본 발명의 GLP-1 유사체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 GLP-1의 특정 위치, 구체적으로 13Y 또는 22F에 알부민을 결합시켜 입체 장애로 인한 약효 감소를 최소화하였다. 또한, 본 발명에 따른 유사체는 알부민과의 결합을 통해 체내 반감기를 증가시켰다. 따라서, 본 발명의 GLP-1 변이체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 당뇨병을 치료하는데 유용하게 사용될 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| title | 1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVE CONJUGATED WITH ALBUMIN |
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