1 GLUCAGON-LIKE PEPTIDE-1 DERIVATIVE CONJUGATED WITH ALBUMIN

The present invention relates to a glucagon-like peptide-1 derivative conjugated with albumin and, more particularly, to a derivative having albumin conjugated with a certain position of the glucagon-like peptide-1 derivative through a linker, a use thereof and a method for preparing the same. Accor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	YANG BYUNG SEOP, KIM SUKHWAN, SEONG JIHYOUN, BAK MI JEONG, KWON INCHAN, CHO JINHWAN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to a glucagon-like peptide-1 derivative conjugated with albumin and, more particularly, to a derivative having albumin conjugated with a certain position of the glucagon-like peptide-1 derivative through a linker, a use thereof and a method for preparing the same. According to the present invention, in case of a GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker, albumin is conjugated with a certain position of GLP-1, particularly 13Y or 22F, thereby minimizing a decrease in a medicinal effect due to a steric hindrance. In addition, the derivative according to the present invention increases a half-life in vivo through conjugation with albumin. Accordingly, the GLP-1 derivative having a GLP-1 mutant conjugated with human serum albumin through a linker may be useful in treating diabetics. 본 발명은 알부민이 결합된 글루카곤 유사 펩타이드-1 유사체에 관한 것이다. 보다 상세하게는 알부민이 링커를 통해 글루카곤 유사 펩타이드-1 유사체의 특정 위치에 결합된 유사체, 이의 용도 및 이의 제조방법에 관한 것이다. 본 발명의 GLP-1 유사체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 GLP-1의 특정 위치, 구체적으로 13Y 또는 22F에 알부민을 결합시켜 입체 장애로 인한 약효 감소를 최소화하였다. 또한, 본 발명에 따른 유사체는 알부민과의 결합을 통해 체내 반감기를 증가시켰다. 따라서, 본 발명의 GLP-1 변이체가 링커를 통해 인간 혈청 알부민과 결합된 GLP-1 유사체는 당뇨병을 치료하는데 유용하게 사용될 수 있다.