35- COMPOSITION COMPRISING 35-DICAFFEOYLQUINIC ACID OR EXTRACT OF CHRYSANTHEMUM AS AN EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING OF MUSCULAR DISORDER OR IMPROVEMENT OF MUSCULAR FUNCTIONS

The present invention relates to a composition for preventing or treating muscular diseases, which contains an extract of Chrysanthemum morifolium and 3,5-dicaffeoylquinic acid as active components. Specifically, since the present invention reduces mRNA expression of atrogin-1 and MuRF-1, which are major biomarkers involved in muscle protein degradation in muscle cells, and reduces muscle loss by increasing mRNA expression of mTOR protein, which is a major biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers associated with muscle differentiation, the present invention can be used for preventing and treating muscular diseases or improving muscle function. In addition, the Chrysanthemum morifolium extract or the 3,5-dicaffeoylquinic acid has an effect of excellently improving exercise performance by increasing the activity of SIRT1 and PCG-1α which are major biomarkers involved in exercise performance. Moreover, since the present invention is a natural product, the present invention can be safely used without side effects and can be used as medicine, food, or cosmetics. 본 발명은 국화 추출물 및 3,5-디카페오일퀴닉에시드(3,5-dicaffeoylquinic acid)를 유효성분으로 함유하는 근육 질환 예방 또는 치료용 조성물에 관한 것으로, 구체적으로, 근육세포에서 근 단백질 분해에 관여하는 주요 생체지표인 atrogin-1과 MuRF-1의 mRNA 발현을 감소시키고, 근 단백질 형성에 관여하는 주요 생체지표인 mTOR 단백질과, 근육 분화 관련 생체지표인 myogenin과 MyoD의 mRNA 발현을 증가시킴으로써 근 손실을 감소시킬 수 있는 바, 근육 질환의 예방, 치료 또는 근 기능 개선에 이용될 수 있다. 또한, 상기 국화 추출물 또는 3,5-디카페오일퀴닉에시드는 운동수행능력에 관여하는 주요 생체지표인 SIRT1 및 PCG-1α의 활성을 증가시킴으로써, 운동수행능력을 탁월하게 향상시키는 효과가 있다. 또한, 본 발명은 천연물이므로 부작용 없이 안전하게 사용될 수 있어, 의약품, 식품 또는 화장품으로 사용될 수 있다.