CS4 Novel Cronobacter sakazakii specific bacteriophage CS4 and antibacterial composition comprising the same

The present invention relates to a novel bacteriophage CS4 having specific killing activity to Cronobacter sakazakii; an antibiotic composition, a feed additive composition, a feed, a disinfectant, a detergent, or a food composition comprising the bacteriophage; a preparation method for Cronobacter...

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Bibliographische Detailangaben
Hauptverfasser:	PARK CHARL SE, YEON YOUNG EUN, HAN BEOM KU, KIM HYUN IL, KIM YOUNG JU
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	AGRICULTURE ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CANDLES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DETERGENT COMPOSITIONS DETERGENTS ENZYMOLOGY FATTY ACIDS THEREFROM FISHING FODDER FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS RECOVERY OF GLYCEROL RESIN SOAPS SOAP OR SOAP-MAKING SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRAPPING USE OF SINGLE SUBSTANCES AS DETERGENTS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a novel bacteriophage CS4 having specific killing activity to Cronobacter sakazakii; an antibiotic composition, a feed additive composition, a feed, a disinfectant, a detergent, or a food composition comprising the bacteriophage; a preparation method for Cronobacter sakazakii-free foods, comprising the step of treating a food with the bacteriophage CS4; and a method for preventing or treating infectious diseases caused by Cronobacter sakazakii, comprising the step of administering the bacteriophage to a non-human subject. The method for preventing or treating infectious diseases caused by Cronobacter sakazakii by using the bacteriophage CS4 shows extremely high specificity to Cronobacter sakazakii compared to other chemicals such as existing antibiotics, and the bacteriophage CS4 infects Cronobacter sakazakii and replicates within the Cronobacter sakazakii, thereby showing excellent bacteriolytic activity. In addition, the bacteriophage CS4 of the present invention does not infect other hosts than bacteria, such as humans, animals, and plants, and thus has the advantages of addressing the problems associated with antibiotics-resistant bacteria due to misuse and overuse of antibiotics, antibiotics remaining in foods, and a broad host range. Accordingly, the bacteriophage CS4 of the present invention can be widely used in the fields relating to the prevention or treatment method for infectious diseases caused by Cronobacter sakazakii in non-human subjects, antibiotic compositions, feed additive compositions, feeds, disinfectants, detergents, or food compositions. 본 발명은 크로노박터 사카자키()에 특이적인 사멸능을 갖는 신규 박테리오파지 CS4, 상기 박테리오파지를 포함하는 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물, 상기 박테리오파지 CS4를 식품에 처리하는 단계를 포함하는 크로노박터 사카자키균이 제거된 식품 제조 방법 및 상기 박테리오파지를 인간을 제외한 개체에 투여하는 단계를 포함하는 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 CS4를 이용한 크로노박터 사카자키에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 크로노박터 사카자키에 대한 특이성이 매우 높고, 상기 박테리오파지 CS4는 상기 크로노박터 사카자키에 감염하여 크로노박터 사카자키 균주 내에서 증식함으로써 용균 활성이 우수하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 CS4는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 CS4는 크로노박터 사카자키에 의한 인간을 제외한 개체의 감염성 질병의 예방 또는 치료방법, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 세척제 또는 식품 조성물 분야에서 다양하게 사용될 수 있다.