PD-1 PD-L1 Phenyl acetylene derivatives as inhibitors of PD-1 and PD-L1 interaction
The present invention relates to a compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof. The compound and the pharmaceutically acceptable salt thereof according to the present invention inhibit interaction of a programmed death 1 (PD-1) protein and a programmed d...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Patent |
| Sprache: | eng ; kor |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | The present invention relates to a compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof. The compound and the pharmaceutically acceptable salt thereof according to the present invention inhibit interaction of a programmed death 1 (PD-1) protein and a programmed death-ligand 1 (PD-L1) protein, thereby being used for preventing or treating diseases related thereto. In chemical formula 1, R_1, R_2, R_3, R_4, R_5, R_6, R_7, R_8, X_1 and X_2 are as defined in the specification.
본 발명은 하기 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염에 관한 것으로, 본 발명에 따른 화합물 및 이의 약학적으로 허용가능한 염은 Programmed death 1 (PD-1) 단백질과 Programmed death-ligand 1 (PD-L1) 단백질의 상호작용을 억제함으로써 이와 관련된 질병의 예방 또는 치료에 유용하게 사용될 수 있다.[화학식 1] 상기 식에서, R, R, R, R, R, R, R, R, X및 X의 정의는 명세서에 정의된 바와 같다. |
|---|