KRAS G12C 억제제

본 발명은 KRas G12C를 억제하는 화합물에 관한 것이다. 특히, 본 발명은 KRas G12C의 활성을 비가역적으로 억제하는 화합물, 상기 화합물을 포함하는 약제학적 조성물 및 그의 사용 방법에 관한 것이다. The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pha...

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Bibliographische Detailangaben
Hauptverfasser:	HINKLIN RONALD JAY, MEJIA MACEDONIO J, VIGERS GUY P.A, FISCHER JOHN P, LEE MATTHEW RANDOLF, FELL JAY BRADFORD, GAUDINO JOHN J, ZECCA HENRY J, TANG TONY P, BLAKE JAMES F, CHRISTENSEN JAMES GAIL, HICKEN ERIK JAMES, MARX MATTHEW ARNOLD, CHICARELLI MARK JOSEPH, BURGESS LAURENCE E, SAVECHENKOV PAVEL
Format:	Patent
Sprache:	kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	본 발명은 KRas G12C를 억제하는 화합물에 관한 것이다. 특히, 본 발명은 KRas G12C의 활성을 비가역적으로 억제하는 화합물, 상기 화합물을 포함하는 약제학적 조성물 및 그의 사용 방법에 관한 것이다. The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.