RNA-30a RNA-30b Radiation sensitizer composition comprising micro RNA-30a and RNA-30b

The present invention relates to a radiation sensitizer composition containing microRNA-30a and RNA-30b as active ingredients. According to the present invention, it has been confirmed that when a non-small cell lung cancer cell line is irradiated with low dose radiation (50 mGy), miR-30a and miR-30...

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Bibliographische Detailangaben
Hauptverfasser:	PARK, GA EUL, YOUN, BU HYUN, KANG, JI HOON
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a radiation sensitizer composition containing microRNA-30a and RNA-30b as active ingredients. According to the present invention, it has been confirmed that when a non-small cell lung cancer cell line is irradiated with low dose radiation (50 mGy), miR-30a and miR-30b which are micro RNAs are expressed. Also, it has been confirmed that miR-30a and miR-30b reduce expression of plasminogen activator inhibitor-1 (PAI-1) induced by high dose radiation irradiation and suppress radiation resistance. Therefore, miR-30a and miR-30b having the above effects are useful as a radiation therapeutic sensitizer composition. When various cancers with reinforced radiation resistance are being treated, radiation treatment efficiency can be improved even with a low dose, and side effects occurring during a high dose radiation treatment can be reduced. 본 발명은 마이크로 RNA-30a 및 RNA-30b를 유효성분으로 함유하는 방사선 민감제 조성물에 관한 것으로, 본 발명에서는 비소세포성 폐암 세포주에 저선량 방사선(50 mGy) 조사 시, 마이크로 RNA인 miR-30a 및 miR-30b가 발현되는 것을 확인하였으며, 상기 miR-30a 및 miR-30b는 고선량 방사선 조사에 의해 유도되는 플라스미노겐 활성인자 억제제-1(plasminogen activator inhibitor-1; PAI-1)의 발현을 감소시키고, 방사선 저항성을 억제하는 것을 확인하였다. 따라서, 상기와 같은 효과를 가지는 miR-30a 및 miR-30b는 방사선 치료 민감제 조성물로 유용하게 활용되어 방사선 저항성이 증대되어 있는 다양한 암 치료 시, 저선량으로도 방사선 치료 효율을 증진시킬 수 있고, 고선량 방사선 치료 시에 나타나는 부작용을 감소시킬 수 있다.