e6- NOVEL CHLORIN E6-CURCUMIN DERIVATIVES PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATMENT OF CANCER

The present invention relates to a novel chlorin e6-curcumin derivative, a manufacturing method thereof and a pharmaceutical composition containing the same for a cancer treatment. Especially, a novel composition is manufactured by using different linkers such as hydrophobic and hydrophilic linkers...

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Bibliographische Detailangaben
Hauptverfasser:	SON, KWANG HEE, KIM, YONG WAN, LEE, HWAN SUK, SHIVAKUMAR S JALDE
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a novel chlorin e6-curcumin derivative, a manufacturing method thereof and a pharmaceutical composition containing the same for a cancer treatment. Especially, a novel composition is manufactured by using different linkers such as hydrophobic and hydrophilic linkers to combine a chlorin e6 with a curcumin. The manufactured composition has superior photophysical properties, stability and an anticancer activity effect. 본 발명은 신규한 클로린 e6-커큐민 유도체, 그 제조방법 및 그것을 함유하는 암 치료용 약학 조성물에 관한 것으로서, 특히, 신규한 화합물은 클로린 e6를 커큐민에 결합시키기 위해 소수성 및 친수성 링커와 같이 서로 다른 링커를 사용함으로써 제조되며, 제조된 화합물은 우수한 광물리적 성질, 안정성 및 항암활성이 나타나는 효과가 있다.