Peptide Nucleic Acid Complex with Increased Cell Permeability and pharmaceutical composition comprising the same
The present invention relates to a nucleic acid complex with a new structure capable of introducing bioactive nucleic acid into cells, a composition for the treatment and diagnosis of diseases including the same, and an expression control method of a target gene using the same. More specifically, th...
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Zusammenfassung: | The present invention relates to a nucleic acid complex with a new structure capable of introducing bioactive nucleic acid into cells, a composition for the treatment and diagnosis of diseases including the same, and an expression control method of a target gene using the same. More specifically, the present invention relates to: a nucleic acid complex where bioactive nucleic acid and carrier peptide nucleic acid modified to generally have a positive charge are complementarily combined to each other; a composition for the treatment and diagnosis of diseases including the same; and an expression control method of a target gene using the same.
본 발명은 생활성 핵산을 세포내에 도입할 수 있는 새로운 구조의 핵산 복합체, 이를 포함하는 질병의 치료 및 진단용 조성물 및 이를 이용한 표적 유전자의 발현 조절 방법에 관한 것으로, 더욱 자세하게는, 생활성 핵산과 전체적으로 양전하를 가지도록 변형된 캐리어 펩티드 핵산(Carrier Peptide Nucleic Acid)이 상보적으로 결합된 핵산 복합체 이를 포함하는 질병의 치료 및 진단용 조성물 및 이를 이용한 표적 유전자의 발현 조절 방법에 관한 것이다. |
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