PREPARATION METHOD FOR HIGHLY PURE TENOFOVIR DISOPROXIL
The present invention discloses a method for manufacturing high purity tenofovir disoproxil. The method comprises the steps of: (i) reacting crude tenofovir disoproxil with muconic acid to manufacture tenofovir disoproxil muconate; (TDM); and (ii) neutralizing the manufactured tenofovir disoproxil m...
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| creator | HAN, GA RAM HAN HAIZHU KIM, HYEON JEONG LEE, IN KYU KIM, A REUM CHUNG, IN HWA MO, KIL WOONG |
| description | The present invention discloses a method for manufacturing high purity tenofovir disoproxil. The method comprises the steps of: (i) reacting crude tenofovir disoproxil with muconic acid to manufacture tenofovir disoproxil muconate; (TDM); and (ii) neutralizing the manufactured tenofovir disoproxil muconate to obtain tenofovir disoproxil. By using the method, 99.7% or more, or 99.9% or more of high purity tenofovir disoproxil can be obtained.
본 명세서에는, 고순도 테노포비어 디소프록실을 제조하는 방법으로서, 상기 방법은, (i) 조 테노포비어 디소프록실(조 TD, crude TENOFOVIR DISOPROXIL)과 뮤콘산(Muconic acid)을 반응시켜 테노포비어 디소프록실 뮤콘산염(TDM)을 제조하는 단계; 및 (ii) 상기 제조된 테노포비어 디소프록실 뮤콘산염을 중화시켜 테노포비어 디소프록실을 수득하는 단계를 포함하는 방법에 개시된다. 상기 방법을 이용하면 99.7% 이상, 또는 99.9% 이상의 고순도 테노포비어 디소프록실을 얻을 수 있다. |
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본 명세서에는, 고순도 테노포비어 디소프록실을 제조하는 방법으로서, 상기 방법은, (i) 조 테노포비어 디소프록실(조 TD, crude TENOFOVIR DISOPROXIL)과 뮤콘산(Muconic acid)을 반응시켜 테노포비어 디소프록실 뮤콘산염(TDM)을 제조하는 단계; 및 (ii) 상기 제조된 테노포비어 디소프록실 뮤콘산염을 중화시켜 테노포비어 디소프록실을 수득하는 단계를 포함하는 방법에 개시된다. 상기 방법을 이용하면 99.7% 이상, 또는 99.9% 이상의 고순도 테노포비어 디소프록실을 얻을 수 있다.</description><language>eng ; kor</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180614&DB=EPODOC&CC=KR&NR=20180064213A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180614&DB=EPODOC&CC=KR&NR=20180064213A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HAN, GA RAM</creatorcontrib><creatorcontrib>HAN HAIZHU</creatorcontrib><creatorcontrib>KIM, HYEON JEONG</creatorcontrib><creatorcontrib>LEE, IN KYU</creatorcontrib><creatorcontrib>KIM, A REUM</creatorcontrib><creatorcontrib>CHUNG, IN HWA</creatorcontrib><creatorcontrib>MO, KIL WOONG</creatorcontrib><title>PREPARATION METHOD FOR HIGHLY PURE TENOFOVIR DISOPROXIL</title><description>The present invention discloses a method for manufacturing high purity tenofovir disoproxil. The method comprises the steps of: (i) reacting crude tenofovir disoproxil with muconic acid to manufacture tenofovir disoproxil muconate; (TDM); and (ii) neutralizing the manufactured tenofovir disoproxil muconate to obtain tenofovir disoproxil. By using the method, 99.7% or more, or 99.9% or more of high purity tenofovir disoproxil can be obtained.
본 명세서에는, 고순도 테노포비어 디소프록실을 제조하는 방법으로서, 상기 방법은, (i) 조 테노포비어 디소프록실(조 TD, crude TENOFOVIR DISOPROXIL)과 뮤콘산(Muconic acid)을 반응시켜 테노포비어 디소프록실 뮤콘산염(TDM)을 제조하는 단계; 및 (ii) 상기 제조된 테노포비어 디소프록실 뮤콘산염을 중화시켜 테노포비어 디소프록실을 수득하는 단계를 포함하는 방법에 개시된다. 상기 방법을 이용하면 99.7% 이상, 또는 99.9% 이상의 고순도 테노포비어 디소프록실을 얻을 수 있다.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAPCHINcAxyDPH091PwdQ3x8HdRcPMPUvDwdPfwiVQICA1yVQhx9fN38w_zDFJw8Qz2Dwjyj_D04WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8d5BRgaGFgYGZiZGhsaOxsSpAgAFjSln</recordid><startdate>20180614</startdate><enddate>20180614</enddate><creator>HAN, GA RAM</creator><creator>HAN HAIZHU</creator><creator>KIM, HYEON JEONG</creator><creator>LEE, IN KYU</creator><creator>KIM, A REUM</creator><creator>CHUNG, IN HWA</creator><creator>MO, KIL WOONG</creator><scope>EVB</scope></search><sort><creationdate>20180614</creationdate><title>PREPARATION METHOD FOR HIGHLY PURE TENOFOVIR DISOPROXIL</title><author>HAN, GA RAM ; HAN HAIZHU ; KIM, HYEON JEONG ; LEE, IN KYU ; KIM, A REUM ; CHUNG, IN HWA ; MO, KIL WOONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20180064213A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2018</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>HAN, GA RAM</creatorcontrib><creatorcontrib>HAN HAIZHU</creatorcontrib><creatorcontrib>KIM, HYEON JEONG</creatorcontrib><creatorcontrib>LEE, IN KYU</creatorcontrib><creatorcontrib>KIM, A REUM</creatorcontrib><creatorcontrib>CHUNG, IN HWA</creatorcontrib><creatorcontrib>MO, KIL WOONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HAN, GA RAM</au><au>HAN HAIZHU</au><au>KIM, HYEON JEONG</au><au>LEE, IN KYU</au><au>KIM, A REUM</au><au>CHUNG, IN HWA</au><au>MO, KIL WOONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION METHOD FOR HIGHLY PURE TENOFOVIR DISOPROXIL</title><date>2018-06-14</date><risdate>2018</risdate><abstract>The present invention discloses a method for manufacturing high purity tenofovir disoproxil. The method comprises the steps of: (i) reacting crude tenofovir disoproxil with muconic acid to manufacture tenofovir disoproxil muconate; (TDM); and (ii) neutralizing the manufactured tenofovir disoproxil muconate to obtain tenofovir disoproxil. By using the method, 99.7% or more, or 99.9% or more of high purity tenofovir disoproxil can be obtained.
본 명세서에는, 고순도 테노포비어 디소프록실을 제조하는 방법으로서, 상기 방법은, (i) 조 테노포비어 디소프록실(조 TD, crude TENOFOVIR DISOPROXIL)과 뮤콘산(Muconic acid)을 반응시켜 테노포비어 디소프록실 뮤콘산염(TDM)을 제조하는 단계; 및 (ii) 상기 제조된 테노포비어 디소프록실 뮤콘산염을 중화시켜 테노포비어 디소프록실을 수득하는 단계를 포함하는 방법에 개시된다. 상기 방법을 이용하면 99.7% 이상, 또는 99.9% 이상의 고순도 테노포비어 디소프록실을 얻을 수 있다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING |
| title | PREPARATION METHOD FOR HIGHLY PURE TENOFOVIR DISOPROXIL |
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