PREPARATION METHOD FOR HIGHLY PURE TENOFOVIR DISOPROXIL

The present invention discloses a method for manufacturing high purity tenofovir disoproxil. The method comprises the steps of: (i) reacting crude tenofovir disoproxil with muconic acid to manufacture tenofovir disoproxil muconate; (TDM); and (ii) neutralizing the manufactured tenofovir disoproxil m...

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Bibliographische Detailangaben
Hauptverfasser:	HAN, GA RAM, HAN HAIZHU, KIM, HYEON JEONG, LEE, IN KYU, KIM, A REUM, CHUNG, IN HWA, MO, KIL WOONG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The present invention discloses a method for manufacturing high purity tenofovir disoproxil. The method comprises the steps of: (i) reacting crude tenofovir disoproxil with muconic acid to manufacture tenofovir disoproxil muconate; (TDM); and (ii) neutralizing the manufactured tenofovir disoproxil muconate to obtain tenofovir disoproxil. By using the method, 99.7% or more, or 99.9% or more of high purity tenofovir disoproxil can be obtained. 본 명세서에는, 고순도 테노포비어 디소프록실을 제조하는 방법으로서, 상기 방법은, (i) 조 테노포비어 디소프록실(조 TD, crude TENOFOVIR DISOPROXIL)과 뮤콘산(Muconic acid)을 반응시켜 테노포비어 디소프록실 뮤콘산염(TDM)을 제조하는 단계; 및 (ii) 상기 제조된 테노포비어 디소프록실 뮤콘산염을 중화시켜 테노포비어 디소프록실을 수득하는 단계를 포함하는 방법에 개시된다. 상기 방법을 이용하면 99.7% 이상, 또는 99.9% 이상의 고순도 테노포비어 디소프록실을 얻을 수 있다.