Glycoengineered Arabidopsis plants for production of plant-made pharmaceuticals and Method for production of plant-made pharmaceuticals using Glycoengineered Arabidopsis plants
The present invention relates to development of a host plant to be used in the production of biodrugs. More specifically, provided is a method for producing biodrugs using plants, to which sugar patterns are adjusted to that of an original protein as much as possible. Moreover, provided is a host pl...
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| creator | PARK, SL KI CHOE, SUNG HWA CHOI, SUN MEE |
| description | The present invention relates to development of a host plant to be used in the production of biodrugs. More specifically, provided is a method for producing biodrugs using plants, to which sugar patterns are adjusted to that of an original protein as much as possible. Moreover, provided is a host plate for producing biodrug. To this end, the method for producing the biodrug using the plant, according to an embodiment of the present invention, includes a step of removing sugar patterns specific to the plant by deleting at least one gene on an enzyme involved in protein sugar chain attachment in plants using a CRISPR gene scissor technique.
본 발명은 바이오의약품 생산시 사용될 기주식물의 개발에 관한 것으로, 당패턴을 최대한 원래 단백질의 패턴으로 맞춘, 식물을 이용한 바이오의약품 생산 방법 및 바이오 의약품 생산을 위한 기주식물을 제공하는 데 그 목적이 있다. 이를 위해 본 발명의 일 양상에 따라 제공되는 식물을 이용한 바이오의약품 생산 방법은, 식물에서 단백질 당쇄 부착에 관여하는 효소의 유전자를 크리스퍼 유전자가위 기술로 하나 이상 삭제하여 식물특이적인 당패턴을 제거하는 단계를 포함하는 것을 특징으로 한다. |
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본 발명은 바이오의약품 생산시 사용될 기주식물의 개발에 관한 것으로, 당패턴을 최대한 원래 단백질의 패턴으로 맞춘, 식물을 이용한 바이오의약품 생산 방법 및 바이오 의약품 생산을 위한 기주식물을 제공하는 데 그 목적이 있다. 이를 위해 본 발명의 일 양상에 따라 제공되는 식물을 이용한 바이오의약품 생산 방법은, 식물에서 단백질 당쇄 부착에 관여하는 효소의 유전자를 크리스퍼 유전자가위 기술로 하나 이상 삭제하여 식물특이적인 당패턴을 제거하는 단계를 포함하는 것을 특징으로 한다.</description><language>eng ; kor</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180607&DB=EPODOC&CC=KR&NR=20180060318A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180607&DB=EPODOC&CC=KR&NR=20180060318A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PARK, SL KI</creatorcontrib><creatorcontrib>CHOE, SUNG HWA</creatorcontrib><creatorcontrib>CHOI, SUN MEE</creatorcontrib><title>Glycoengineered Arabidopsis plants for production of plant-made pharmaceuticals and Method for production of plant-made pharmaceuticals using Glycoengineered Arabidopsis plants</title><description>The present invention relates to development of a host plant to be used in the production of biodrugs. More specifically, provided is a method for producing biodrugs using plants, to which sugar patterns are adjusted to that of an original protein as much as possible. Moreover, provided is a host plate for producing biodrug. To this end, the method for producing the biodrug using the plant, according to an embodiment of the present invention, includes a step of removing sugar patterns specific to the plant by deleting at least one gene on an enzyme involved in protein sugar chain attachment in plants using a CRISPR gene scissor technique.
본 발명은 바이오의약품 생산시 사용될 기주식물의 개발에 관한 것으로, 당패턴을 최대한 원래 단백질의 패턴으로 맞춘, 식물을 이용한 바이오의약품 생산 방법 및 바이오 의약품 생산을 위한 기주식물을 제공하는 데 그 목적이 있다. 이를 위해 본 발명의 일 양상에 따라 제공되는 식물을 이용한 바이오의약품 생산 방법은, 식물에서 단백질 당쇄 부착에 관여하는 효소의 유전자를 크리스퍼 유전자가위 기술로 하나 이상 삭제하여 식물특이적인 당패턴을 제거하는 단계를 포함하는 것을 특징으로 한다.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqVjr0KwkAQhNNYiPoOC9aBiwFJG8QfEBuxD-vdXnKQ7B53l8K38hENaK9WU8z3DTPPnsf-oYW4dUwUyEAd8O6M-Ogi-B45RbASwAcxo05OGMS-i3xAQ-A7DANqGpPT2EdANnCh1In5zxuj4xa-v1lmMzvxtPrkIlsf9rfdKScvDUU_TTKl5nzdqKJSaqvKoqrL36gXs3BdjQ</recordid><startdate>20180607</startdate><enddate>20180607</enddate><creator>PARK, SL KI</creator><creator>CHOE, SUNG HWA</creator><creator>CHOI, SUN MEE</creator><scope>EVB</scope></search><sort><creationdate>20180607</creationdate><title>Glycoengineered Arabidopsis plants for production of plant-made pharmaceuticals and Method for production of plant-made pharmaceuticals using Glycoengineered Arabidopsis plants</title><author>PARK, SL KI ; CHOE, SUNG HWA ; CHOI, SUN MEE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_KR20180060318A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; kor</language><creationdate>2018</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>PARK, SL KI</creatorcontrib><creatorcontrib>CHOE, SUNG HWA</creatorcontrib><creatorcontrib>CHOI, SUN MEE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PARK, SL KI</au><au>CHOE, SUNG HWA</au><au>CHOI, SUN MEE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Glycoengineered Arabidopsis plants for production of plant-made pharmaceuticals and Method for production of plant-made pharmaceuticals using Glycoengineered Arabidopsis plants</title><date>2018-06-07</date><risdate>2018</risdate><abstract>The present invention relates to development of a host plant to be used in the production of biodrugs. More specifically, provided is a method for producing biodrugs using plants, to which sugar patterns are adjusted to that of an original protein as much as possible. Moreover, provided is a host plate for producing biodrug. To this end, the method for producing the biodrug using the plant, according to an embodiment of the present invention, includes a step of removing sugar patterns specific to the plant by deleting at least one gene on an enzyme involved in protein sugar chain attachment in plants using a CRISPR gene scissor technique.
본 발명은 바이오의약품 생산시 사용될 기주식물의 개발에 관한 것으로, 당패턴을 최대한 원래 단백질의 패턴으로 맞춘, 식물을 이용한 바이오의약품 생산 방법 및 바이오 의약품 생산을 위한 기주식물을 제공하는 데 그 목적이 있다. 이를 위해 본 발명의 일 양상에 따라 제공되는 식물을 이용한 바이오의약품 생산 방법은, 식물에서 단백질 당쇄 부착에 관여하는 효소의 유전자를 크리스퍼 유전자가위 기술로 하나 이상 삭제하여 식물특이적인 당패턴을 제거하는 단계를 포함하는 것을 특징으로 한다.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Glycoengineered Arabidopsis plants for production of plant-made pharmaceuticals and Method for production of plant-made pharmaceuticals using Glycoengineered Arabidopsis plants |
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