Cudrania tricuspidata Pharmaceutical composition containing the extracts by Cudrania tricuspidata fruit for the improvement of memory and cognition ability Health functional Food containing the extracts

The present invention relates to a pharmaceutical composition containing extracts of a Cudrania tricuspidata fruit for improvement of memory and cognition ability, and to health functional food containing the same as an active ingredient. The pharmaceutical composition of the present invention reduces the activity of acetylcholinesterase, which is a neurotransmitter enzyme, increases the activity of ERK and CREB, which are cognitive and memory related proteins, increases the amount of acetylcholine, a neurotransmitter in the blood, increases the expression and activity of AMPK, CREB and SIRT3, which are cognitive and memory related proteins, and can improve cognition and memory ability through the expression of neurogenesis and neuronal cell differentiation related genes. 본 발명은 꾸지뽕나무(Cudrania tricuspidata)열매 추출물을 함유하는 인지, 기억 증진용 약학적 조성물, 이를 유효성분으로 포함하는 건강기능식품에 관한 것이다. 본 발명의 약학적 조성물은 신경전달물질 분해효소인 acetylcholinesterase의 활성을 감소시키고, 인지 및 기억 관련 단백질인 ERK와 CREB의 활성을 증가시키고, 혈액에서 신경전달물질인 acetylcholine 함량을 증가시키고, 인지 및 기억 관련 단백질인 AMPK, CREB 및 SIRT3의 발현 및 활성을 증가시키고, neurogenesis 및 neuronal cell differentiation 관련 유전체의 발현을 통해 인지 및 기억 능력을 개선할 수 있다.