S-N-3-6--3--1H--5--1-2-4-4-1--1H-124--3--36--12H--2--3--3- S-N-3-6-ISOPROPOXYPYRIDIN-3-YL-1H-INDAZOL-5-YL-1-2-4-4-1-METHYL-1H-124-TRIAZOL-3-YLPHENYL-36-DIHYDROPYRIDIN-12H-YL-2-OXOETHYL-3-METHYLTHIOPYRROLIDINE-3-CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS

본 발명은 유효 성분 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드를 포함하고, 여기서 유효 성분의 총량은 약 60-90 중량%의 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드 형태 1 HCl, 약 10-30 중량%의 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드 비결정질 HCl, 및 약 0-5 중량%의 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드 비결정질 유리 염기를 포함하는 것인 과립 조성물을 포함한다. The invention includes a granular composition comprising the active ingredient (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide, wherein a total amount of active ingredient comprises by weight % about 60-90% (S)-N-(3-(6-isopro-poxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-di-hydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide Form 1 HCl, about 10-30% (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous HCl, and about 0-5% (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide amorphous free base.