FARNESOID X RECEPTOR AGONIST CONTAINING EXTRACT OF PLATYCODON GRANDIFLORUM AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FATTY LIVER CONTAINING THE SAME

The present invention relates to a farnesoid X receptor (FXR) agonist closely associated with fatty liver disease, containing bellflower root-derived saponin or a bellflower root extract containing the bellflower root-derived saponin as an active ingredient. The composition of the present invention...

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Bibliographische Detailangaben
Hauptverfasser:	PARK, EUL YONG, GIM, JONG U
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a farnesoid X receptor (FXR) agonist closely associated with fatty liver disease, containing bellflower root-derived saponin or a bellflower root extract containing the bellflower root-derived saponin as an active ingredient. The composition of the present invention acts as the FXR agonist, inhibits lipogenesis, and promotes fatty acid oxidation, thereby exhibiting outstanding effects of suppressing neutral fat accumulation in liver tissues. Thus, the composition can be useful as functional health foods for ameliorating fatty liver disease and compositions for preventing and treating fatty liver disease. 본 발명은 도라지 사포닌 또는 이를 포함하는 도라지 추출물을 유효성분으로 함유하는 지방간 질환과 밀접한 관련이 있는 FXR (파네소이드 X 수용체) 항진제에 관한 것으로, 본 발명의 조성물은 FXR 항진제로 작용하여 지방의 합성을 억제하고 지방산 산화를 촉진하여 간 조직 내에서의 중성지방 축적 억제 효과가 탁월하므로 지방간 질환의 예방 및 치료용 조성물 및 지방간 질환 개선 건강기능식품으로 유용하게 사용될 수 있다.