CRYSTALLINE FORMS OF ANTIVIRAL SOFOSBUVIR ANALOGUES

항-HCV 화합물인, 하기 (S)-이소프로필 2-((S)-(((2R,3R,4R,5R)-5-(2,4-디옥소-3,4-디히드로피리미딘-1(2H)-일)-4-플루오로-3-히드록시-4-메틸테트라히드로푸란-2-일)메톡시)(페녹시)포스포릴아미노)프로파노에이트 (화합물 I)의 결정질 고체 형태를 기술한다. 상기 결정질 형태를 제조하는 방법 및 사용하는 방법 또한 제공한다: (화합물 I). Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2...

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Bibliographische Detailangaben
Hauptverfasser:	SEO MUN SIK, CASTEEL MELISSA JEAN, DASHNER KATHLEEN, SHI BING, ZIA VAHID, JUNG HYUK JUN, WANG FANG
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Zusammenfassung:	항-HCV 화합물인, 하기 (S)-이소프로필 2-((S)-(((2R,3R,4R,5R)-5-(2,4-디옥소-3,4-디히드로피리미딘-1(2H)-일)-4-플루오로-3-히드록시-4-메틸테트라히드로푸란-2-일)메톡시)(페녹시)포스포릴아미노)프로파노에이트 (화합물 I)의 결정질 고체 형태를 기술한다. 상기 결정질 형태를 제조하는 방법 및 사용하는 방법 또한 제공한다: (화합물 I). Crystalline solid forms of the anti-HCV compound (S)-isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2- yl)methoxy)(phenoxy)phosphorylamino)propanoate (Compound I) are described Also provided are processes of making and methods of using the crystalline forms.