METHOD FOR PREPARING TICAGRELOR AND NOVEL INTERMEDIATE USED THEREFOR

METHOD FOR PREPARING TICAGRELOR AND NOVEL INTERMEDIATE USED THEREFOR

The present invention relates to a novel synthesis method for Ticagrelor, represented by chemical formula 1, (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, and novel intermediates f...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KIM, YONG JIK, KIM, JAE HAN, SHIN, CHANG YONG, LIM, JOONG IN, CHA, DAE WON, KWAK, WOO YOUNG, KIM, HOO SOOK
Format: Patent
Sprache:eng ; kor
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a novel synthesis method for Ticagrelor, represented by chemical formula 1, (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol, and novel intermediates for use in the novel synthesis method. According to the present invention, Ticagrelor can be easily synthesized from the novel intermediates. 본 발명은 하기 화학식 1로 표시되는 티카그렐러, (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-디플루오로페닐)시클로프로필아미노]-5-(프로필티오)-3-[1,2,3]트리아졸로[4,5-]피리미딘-3-일]-5-(2-히드록시에톡시)시클로펜탄-1,2-디올의 신규한 제조방법 및 이에 사용되는 신규 중간체들에 관한 것이다. 본 발명에 따르면 티카그렐러를 신규한 중간체로부터 용이하게 제조할 수 있다: