ENZYMATIC PROCESS FOR THE REGIOSELECTIVE MANUFACTURING OF N-FMOC-DOXORUBICIN-14-O-DICARBOXYLIC ACID MONO ESTERS

According to the present invention, disclosed is a selective synthetic method of N-Fmoc-doxorubicin-14-O-dicarboxylic acid monoester derivative using lipase enzyme and a bis-acyl donor compound, for example, a dicarboxylic acid or an anhydride, starting from N-Fmoc-doxorubicin. 본 발명은-Fmoc-독소루비신으로부터...

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Bibliographische Detailangaben
Hauptverfasser:	GERLACH MATTHIAS, SCHUSTER TILMANN, SCHUCH FALK
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	According to the present invention, disclosed is a selective synthetic method of N-Fmoc-doxorubicin-14-O-dicarboxylic acid monoester derivative using lipase enzyme and a bis-acyl donor compound, for example, a dicarboxylic acid or an anhydride, starting from N-Fmoc-doxorubicin. 본 발명은-Fmoc-독소루비신으로부터 출발하여, 리파제 효소 및 비스-아실 공여체 화합물 예를 들면, 디카복실산 또는 무수물을 사용하는-Fmoc-독소루비신-14--디카복실산 모노 에스테르 유도체의 선택적 합성 방법을 기재한다.