AMFR-FC FUSION PROTEIN AND ANTI CANCER USES THEREOF

The present invention relates to an AMFR-Fc fusion protein of which autocrine motility factor receptor (AMFR) protein and a human immunoglobulin Fc region are fused together. The present invention further relates to a used thereof for preventing or treating cancer. According to the present invention...

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Bibliographische Detailangaben
Hauptverfasser:	WANG, JIN SANG, JUNG, HAHN SUN, MYUNG, JAY HYUK, JEON, BYEONG WOOK, KANG, SEUNG HOON, YANG, EUN HEE
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to an AMFR-Fc fusion protein of which autocrine motility factor receptor (AMFR) protein and a human immunoglobulin Fc region are fused together. The present invention further relates to a used thereof for preventing or treating cancer. According to the present invention, the AMFR-Fc fusion protein effectively inhibits proliferation of cancer cells induced by over-expression of autocrine motility factor (AMF) in various cancerous tissues in stomach cancer and breast cancer, thereby exhibiting excellent effects of preventing or treating various cancers. 본 발명은 AMFR (Autocrine motility factor receptor) 단백질과 인간 면역글로불린 Fc 영역이 융합된 AMFR-Fc 융합 단백질 및 이의 암 예방 또는 치료 용도에 관한 것이다. 본 발명에 따른 AMFR-Fc 융합 단백질은 위암, 유방암 등 각종 암조직에서 AMF의 과발현에 의해 유도되는 암세포의 증식을 효과적으로 억제함으로써, 각종 암에 대하여 우수한 암 예방 또는 치료 효과를 나타낸다.