A QUANTITATIVE METHOD FOR PROTEIN IN BIOLOGICAL SAMPLE USING MASS SPECTROMETRY AND A COMPOSITION THEREFOR

The present invention relates to a method for quantitatively analyzing protein in a biological sample of a protein medicine product and a composition thereof wherein protein-specific fragment peptide by enzyme treatment, fragment peptide including glycan, medicine synthetic peptide of protein includ...

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Bibliographische Detailangaben
Hauptverfasser:	HWANG, DONG HWI, YEO, YOUN JEE, BANG, JOO YOUNG, KANG, GUM YONG, BAEK, JE HYUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a method for quantitatively analyzing protein in a biological sample of a protein medicine product and a composition thereof wherein protein-specific fragment peptide by enzyme treatment, fragment peptide including glycan, medicine synthetic peptide of protein including stable isotope for quantification, labeling for quantification similar to the same, the fragments, and the total protein are quantified by using direct mass spectrometry. 본 발명은 단백질의약품의 생체시료내 정량분석법 및 그 조성물에 관한 것으로서, 효소처리에 의한 단백질 특이적인 단편 펩티드, 글라이칸 포함 단편 펩티드, 정량을 목적으로 하는 Stable-isotope가 포함된 단백질의약품 합성 펩티드, 이와 유사한 정량목적 표지화 그리고 이 단편 및 단백질 전체를 직접 질량분석을 이용하여 정량하고자 하는 질량분석 방법 및 그 조성물에 관한 것이다.