RECOMBINANT CALCIUM BINDING PROTEINS AND NANOFIBROUS WEB CONTAINING THE SAME

The present invention can prepare a chitosan nanofiber support containing calcium-binding proteins by mixing recombinant calcium-binding proteins to a polymer. The nanofiber support which contains the calcium-binding proteins for bone tissue reproduction can be coated with calcium carbonate through...

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Bibliographische Detailangaben
Hauptverfasser:	CHOI, YOO SEONG, KIM, HYE RIN, SONG, WOO HO
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMISTRY DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METALLURGY METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The present invention can prepare a chitosan nanofiber support containing calcium-binding proteins by mixing recombinant calcium-binding proteins to a polymer. The nanofiber support which contains the calcium-binding proteins for bone tissue reproduction can be coated with calcium carbonate through a bio-mineralization process while also being able to be easily coupled to the calcium in order to contain the calcium in the support. The chitosan nanofiber support containing calcium-binding proteins is expected to promote growth and differentiation of osteoblasts when being grafted on and filling a damaged bone tissue, thereby being utilized as a novel bioactive support for bone tissue reproduction. 본 발명에서는 고분자에 재조합 칼슘 결합 단백질을 혼합하여, 칼슘 결합 단백질을 함유하는 키토산 나노섬유 지지체를 제조하였다. 칼슘 결합 단백질이 함유된 골조직 재생용 나노섬유 지지체는, 칼슘과 용이하게 결합하여 칼슘을 지지체에 손쉽게 함유할 수 있을 뿐만 아니라 바이오미네랄화 과정에 의해 탄산칼슘으로 코팅될 수 있어, 손상된 골조직에 이식 및 충진되었을 때 조골세포의 성장과 분화를 촉진할 것으로 기대되어 새로운 골조직 재생용 생체활성 지지체로써 활용될 것으로 판단된다.