NOVEL CYCLOHEXENE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF THE METABOLIC DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT

The present invention relates to cyclohexene derivatives, a method for producing the same, and a pharmaceutical composition for preventing or treating metabolic diseases, containing the same as an active ingredient. The cyclohexene derivatives in accordance with the present invention activate G protein-coupled receptor 119 (GPR-119) to increase intracellular activity of cyclic adenosine monophosphate (cAMP), and induce the release of neurosecretion protein glucagon-like peptide-1 (GLP-1) to simultaneously cause weight loss and a drop in blood sugar level. Therefore, the cyclohexene derivatives can be effectively used as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesteremia, dyslipidemia, X syndrome, and the like. 본 발명은 싸이클로 헥센 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 싸이클로 헥센 유도체는 GPR-119(G protein-coupled receptor 119)를 활성화시켜 cAMP(Cyclic adenosine monophosphate)의 세포 내 활성을 증가시키고, 신경 내분비 단백질인 GLP-1(Glucagon-like peptide-1) 방출을 유도하여 체중감소 및 혈당강하 효과가 동시에 나타나므로, 비만, I형 당뇨병, Ⅱ형 당뇨병, 부적합한 내당증, 인슐린 내성증, 고혈당증, 고지질혈증, 고중성지방혈증, 고콜레스테롤혈증, 이상지질혈증, X 증후군 등과 같은 대사성 질환의 예방 또는 치료용 약학적 조성물로 유용하게 사용할 수 있다.