IMPROVED PROCESS FOR PREPARING OSELTAMIVIR

IMPROVED PROCESS FOR PREPARING OSELTAMIVIR

The present invention relates to an improved method for preparing oseltamivir phosphate represented by chemical formula 1. More specifically, the present invention provides a method for preparing oseltamivir phosphate with high purity represented by chemical formula 1, wherein 5-azido oseltamivir re...

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Hauptverfasser: CHOI, MIN SIK, SON, HOE JOO, KWON, HYEOK BEOM, BANG, SUNG HUN
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Sprache:eng ; kor
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
COMPOUNDS THEREOF
INORGANIC CHEMISTRY
METALLURGY
NON-METALLIC ELEMENTS
ORGANIC CHEMISTRY
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creator CHOI, MIN SIK
SON, HOE JOO
KWON, HYEOK BEOM
BANG, SUNG HUN
description The present invention relates to an improved method for preparing oseltamivir phosphate represented by chemical formula 1. More specifically, the present invention provides a method for preparing oseltamivir phosphate with high purity represented by chemical formula 1, wherein 5-azido oseltamivir represented by chemical formula 3 is reduced into Lewis acid metal chloride represented by chemical formula 4 to synthesize oseltamivir represented by chemical formula 2, and then oseltamivir represented by chemical formula 2 is converted into phosphate to prepare oseltamivir phosphate. In reaction formula above, x is 0 or 2.
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More specifically, the present invention provides a method for preparing oseltamivir phosphate with high purity represented by chemical formula 1, wherein 5-azido oseltamivir represented by chemical formula 3 is reduced into Lewis acid metal chloride represented by chemical formula 4 to synthesize oseltamivir represented by chemical formula 2, and then oseltamivir represented by chemical formula 2 is converted into phosphate to prepare oseltamivir phosphate. 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More specifically, the present invention provides a method for preparing oseltamivir phosphate with high purity represented by chemical formula 1, wherein 5-azido oseltamivir represented by chemical formula 3 is reduced into Lewis acid metal chloride represented by chemical formula 4 to synthesize oseltamivir represented by chemical formula 2, and then oseltamivir represented by chemical formula 2 is converted into phosphate to prepare oseltamivir phosphate. 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More specifically, the present invention provides a method for preparing oseltamivir phosphate with high purity represented by chemical formula 1, wherein 5-azido oseltamivir represented by chemical formula 3 is reduced into Lewis acid metal chloride represented by chemical formula 4 to synthesize oseltamivir represented by chemical formula 2, and then oseltamivir represented by chemical formula 2 is converted into phosphate to prepare oseltamivir phosphate. In reaction formula above, x is 0 or 2.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
COMPOUNDS THEREOF
INORGANIC CHEMISTRY
METALLURGY
NON-METALLIC ELEMENTS
ORGANIC CHEMISTRY
title IMPROVED PROCESS FOR PREPARING OSELTAMIVIR
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