ANTIBODY VARIANT WITH CYSTEINE RESIDUES, ANTIBODY-DRUG CONJUGATE COMPRISING THE ANTIBODY VARIANT, AND METHOD OF MANUFACTURING THEREOF

The present invention relates to an antibody in which a motif consisting of a peptide or an amino acid including one or more cysteine residues is bound to a terminal, and particularly a medium-chain terminal of the parent antibody; a modified antibody-drug conjugate (mADC) in which the antibody and...

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Bibliographische Detailangaben
Hauptverfasser:	CHUNG, HYE SHIN, KIM, YONG MO, KWON, SUN HOON, YOU, SUN AH, PARK, SOON JAE, LEE, SUN BAE
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to an antibody in which a motif consisting of a peptide or an amino acid including one or more cysteine residues is bound to a terminal, and particularly a medium-chain terminal of the parent antibody; a modified antibody-drug conjugate (mADC) in which the antibody and a drug are bound; and a method for producing the antibody or the modified antibody-drug conjugate. The mADC according to the present invention is highly specific to antigens of the antibody included in the conjugate and so can accurately deliver the drug to target cells. Therefore, the mADC can increase the therapeutic effect and can also bring about greater utilization of drugs and particularly anticancer drugs and the like of which use is limited due to toxicity despite being highly effective. Moreover, the present invention relates to a composition for treating diseases and particularly cancer by using the mADC. 본 발명은 하나 이상의 시스테인 잔기를 포함한 아미노산 또는 펩티드로 이루어진 모티프(motif)가 모항체의 말단, 특히 중쇄 말단에 결합된 항체, 그러한 항체와 약물이 결합된 변형항체-약물 접합체(mADC, Antibody-Drug Conjugate) 및 상기 항체 또는 변형항체-약물 접합체의 제조방법에 대한 것이다. 본 발명에 따른 변형항체-약물 접합체(mADC, Antibody-Drug Conjugate)는 접합체에 포함된 항체의 항원에 대한 높은 특이성으로 인해 타겟 세포에 약물을 정확하게 전달할 수 있어, 치료효과를 높일 수 있으며, 또한 높은 효과에도 불구하고 독성으로 인해 사용이 제한적인 약물, 특히 항암제 등의 활용도를 제고할 수 있다. 또한, 본 발명은 상기 변형항체-약물 접합체를 이용한 질병, 특히 암의 치료용 조성물에 대한 것이다.