PROCESS FOR PREPARING FLOMOXEF SODIUM

The present invention relates to a crystallization method of flomoxef sodium used among oxacephem-based antibiotics, comprising the steps of: dissolving flomoxef acid in a solvent; reacting organic or inorganic sodium salts by adding a dissolved solution; cooling a reaction solution; and crystallizi...

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Bibliographische Detailangaben
Hauptverfasser:	MOON, CHANG SANG, BYUN, YOUNG SEOK, KIM, HYO JUN, OH, GI BUM, AN, SANG GEUN
Format:	Patent
Sprache:	eng ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a crystallization method of flomoxef sodium used among oxacephem-based antibiotics, comprising the steps of: dissolving flomoxef acid in a solvent; reacting organic or inorganic sodium salts by adding a dissolved solution; cooling a reaction solution; and crystallizing flomoxef sodium. According to the present invention, flomoxef sodium is manufactured by the crystallization method, compare to a freeze-drying method which is time consuming and expensive. Therefore, high-yield of flomoxef sodium can be obtained with a simple method in general production facilities in significantly shortened time with no need to pay costs for freeze-drying installation. 본 발명은 옥사세펨(oxacephem)계 항생제 중에서 유용하게 사용되는 플로목세프 소디움(flomoxef sodium)을 결정화 방법으로 얻는 방법에 관한 것으로, 플로목세프 산을 용매에 용해시키고, 유기 또는 무기 소디움염을 용해시킨 용액을 가하여 반응시킨 후, 반응액을 냉각하여 플로목세프 소디움을 결정화시키는 단계를 포함한다. 본 발명의 방법에 따르면, 플로목세프 소디움을 시간과 비용이 많이 드는 동결건조법이 아닌 결정화 방법으로 제조하기 때문에, 동결건조 설비 비용이 필요 없고 일반 생산 시설에서 현저하게 단축된 시간 내에 용이한 방법으로 플로목세프 소디움을 고수율로 얻을 수 있다.